Results 71 to 80 of about 1,264,950 (306)

Defective germinal center selection results in persistence of self-reactive B cells from the primary to the secondary repertoire in Primary Antiphospholipid Syndrome

Nature Communications
Primary antiphospholipid syndrome (PAPS) is a life-threatening clotting disorder mediated by pathogenic autoantibodies. Here we dissect the origin of self-reactive B cells in human PAPS using peripheral blood and bone marrow of patients with triple ...
Yannick Dieudonné, Raquel Lorenzetti, Julien Rottura, Iga Janowska, Quentin Frenger, Léa Jacquel, Olivier Vollmer, Francesco Carbone, Zhu Chengsong, Marine Luka, Sabine Depauw, Nadège Wadier, Stéphane Giorgiutti, Benoît Nespola, Agathe Herb, Reinhard Edmund Voll, Aurélien Guffroy, Vincent Poindron, Mickaël Ménager, Thierry Martin, Pauline Soulas-Sprauel, Marta Rizzi, Anne-Sophie Korganow, Vincent Gies   +23 more
doaj   +1 more source

Subjective assessment of sleep quality in adult patients with hereditary angioedema

Frontiers in Neurology
BackgroundHereditary angioedema (HAE) is a rare disorder characterized by recurrent swelling episodes, including painful abdominal attacks and life-threatening angioedema of the larynx that significantly affects patients’ quality of life, including sleep.
Esra Karabiber, Ezgi Yalçın Güngören, Ezgi Yalçın Güngören, Ezgi Yalçın Güngören, Ahmet Özen, Ahmet Özen, Ahmet Özen, Safa Barış, Safa Barış, Safa Barış, Elif Karakoc-Aydiner, Elif Karakoc-Aydiner, Elif Karakoc-Aydiner   +12 more
doaj   +1 more source

Recombinant human hyaluronidase-facilitated subcutaneous immunoglobulin infusion in primary immunodeficiency diseases.

Immunotherapy, 2017
Most primary immunodeficiency diseases (PIDDs) resulting in antibody deficiency require intravenous or subcutaneous immunoglobulin G (SCIG) replacement therapy.
R. Wasserman
semanticscholar   +1 more source

Interaction of human immunodeficiency and papilloma viruses: association with anal epithelial abnormality in homosexual men

, 1990
Caussy D, Goedert JJ, Palefsky J, et al. Interaction of human immunodeficiency and papilloma viruses: association with anal epithelial abnormality in homosexual men. International Journal of Cancer.
Colclough, Ginga, Wiktor, Stefan Z., Palefsky, Joel, Sanchez, William C., Grossman, Ronald J., Blattner, William A., Biggar, Robert J., Krämer, Alexander ; https://orcid.org/, Goedert, James J., Gonzales, John, Rabkin, Charles S., Caussy, Deoraj, DiGioia, Richard A.   +12 more
core   +1 more source

The primary immunodeficiency disorders [PDF]

, 2017
The primary immunodeficiency disorders are clinically heterogeneous diseases, the majority of which arise from inborn errors in immunologically relevant genes.
Patel, Smita Y, Adrian M. Shields, Shields, Adrian; id_orcid, Smita Y. Patel   +3 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Stem Cell Transplantation for Primary Immunodeficiency Disease: Experience of a Singapore Hospital

World Allergy Organization Journal, 2012
We retrospectively analyzed the outcomes of hematopoietic stem cell transplantation in 7 patients with primary immunodeficiency diseases treated at the National University Hospital, Singapore, over the period from December 1996 to January 2010.
Alison Joanne Lee, MBBS, MRCPCH, MMed, Jethro Wu, MBBS, Mariflor Sarmiento Villegas, MD, Lynette Pei-Chi Shek, MBBS, MRCP, Bee-Wah Lee, MBBS, MMed, MD, FRCP, FRCPCh, FAAAAI, Poh-Lin Tan, MBBS, MMed   +5 more
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Early Recognition of Treatment‐Responsive Rapidly Progressive Dementia: The Modified STAM3mP Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Early identification of patients with treatment‐responsive rapidly progressive dementia (RPD) is important as early treatment improves outcomes. The STAM3P score identifies treatment‐responsive RPD using “high risk” presenting features. We optimized performance by adding a time component (i.e., dementia within 3 months) and validated the ...
R. W. van Steenhoven, N. Satyadev, A. E. M. Bastiaansen, Y. D. Piura, J. Kerstens, Y. S. Crijnen, J. Brenner, T. Brand, T. M. Bienfait, S. Veenbergen, J. M. de Vries, F. J. de Jong, E. G. P. Dopper, P. A. E. Sillevis Smitt, H. Seelaar, G. S. Day, M. J. Titulaer   +16 more
wiley   +1 more source

Primary Immunodeficiency Diseases in Highly Consanguineous Populations from Middle East and North Africa: Epidemiology, Diagnosis, and Care

Frontiers in Immunology, 2017
Middle East and North Africa region (MENA)1 populations are of different ethnic origins. Consanguineous marriages are common practice with an overall incidence ranging between 20 and 50%.
H. Al-Mousa, B. Al-Saud
semanticscholar   +1 more source