Results 61 to 70 of about 1,264,950 (306)

Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency

, 2007
Common Variable Immunodeficiency belongs to the group of rare diseases encompassing antibody deficiency syndromes of highly variable clinical presentation and outcome.
Claudio Pignata, Simona Donnanno, Franco Dammacco, A. M. Pesce, Network Within The Ipinet Italian Primary Immunodeficiency, Annarosa Soresina, QUINTI, Isabella, Carlo Agostini, Andrea Guerra, Silvana Martino, Alessandro Plebani, Roberto Rondelli, Giuseppe Spadaro, Federica Borghese   +13 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Evaluation of MicroRNA-125b-5p and Transcription Factors BLIMP1 and IRF4 Expression in Unsolved Common Variable Immunodeficiency Patients

Iranian Journal of Allergy, Asthma and Immunology, 2021
Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary humoral immunodeficiencies characterized by failure in the final differentiation of B lymphocytes. The majority of CVID cases have no identified genetic defect, and
Zahra Hamidi Esfahani, Reza Yazdani, Sepideh Shahkarami, Fateme Babaha, Hassan Abolhassani, Maryam Sadr, Ali Akbar Pourfathollah, Asghar Aghamohammadi   +7 more
doaj   +1 more source

Primary immunodeficiency diseases – genomic approaches delineate heterogeneous Mendelian disorders

Journal of Allergy and Clinical Immunology, 2016
Background: Primary immunodeficiency diseases (PIDDs) are clinically and genetically heterogeneous disorders thus far associated with mutations in more than 300 genes. The clinical phenotypes derived from distinct genotypes can overlap.
A. Stray-Pedersen, H. Sorte, P. Samarakoon, T. Gambin, Ivan K. Chinn, Zeynep Coban Akdemir, H. C. Erichsen, L. Forbes, Shen Gu, Bo Yuan, S. Jhangiani, D. Muzny, O. Rødningen, Y. Sheng, S. Nicholas, L. Noroski, F. Seeborg, C. Davis, D. Canter, E. Mace, T. Vece, C. Allen, H. Abhyankar, Philip M Boone, C. Beck, W. Wiszniewski, B. Fevang, P. Aukrust, G. Tjønnfjord, T. Gedde-Dahl, H. Hjorth-Hansen, I. Dybedal, I. Nordøy, S. Jørgensen, T. Abrahamsen, Torstein Øverland, A. Bechensteen, V. Skogen, L. Osnes, M. Kulseth, T. Prescott, C. Rustad, K. Heimdal, J. Belmont, N. Rider, J. Chinen, Tram N. Cao, Eric A. Smith, M. S. Caldirola, L. Bezrodnik, S. L. Lugo Reyes, F. E. Espinosa Rosales, Nina Denisse Guerrero-Cursaru, L. A. Pedroza, Cecilia Poli, J. Franco, C. M. Trujillo Vargas, J. C. Aldave Becerra, N. Wright, T. Issekutz, A. Issekutz, J. Abbott, J. Caldwell, D. Bayer, A. Chan, A. Aiuti, C. Cancrini, E. Holmberg, C. West, Magnus Burstedt, E. Karaca, G. Yeşil, H. Artaç, Y. Bayram, M. M. Atik, M. Eldomery, Mohammad S. Ehlayel, S. Jolles, B. Flatø, A. Bertuch, I. C. Hanson, V. Zhang, L. Wong, Jianhong Hu, M. Walkiewicz, Yaping Yang, C. Eng, E. Boerwinkle, R. Gibbs, W. Shearer, R. Lyle, J. Orange, J. Lupski   +92 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A patient with complete IFN-γR1 deficiency and tuberculosis resembling BCG diseaseIFN-γR1 deficiency and Mycobacterium tuberculosis [PDF]

Journal of Human Immunity
We present a case of a patient with a deleterious variant in IFNGR1 who contracted Mycobacterium tuberculosis. However, the patient presented with clinical manifestations suggestive of BCG infection.
Sara Espinosa-Padilla, Héctor Gómez-Tello, Carlos Sanchez-Flores, Uriel Pérez-Blanco, Tiareth Cova-Guzmán, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Lizbeth Blancas-Galicia   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Safety and tolerability of subcutaneous immunoglobulin 20% in primary immunodeficiency diseases from two continents.

Immunotherapy, 2019
Aim: This pooled analysis evaluated the safety and tolerability of the subcutaneous immunoglobulin 20% product, Ig20Gly, in primary immunodeficiency diseases using data from two Phase II/III studies conducted in North America and Europe.
D. Suez, G. Kriván, S. Jolles, M. Stein, Sudhir Gupta, K. Paris, P. V. van Hagen, N. Brodszki, W. Engl, H. Leibl, B. McCoy, L. Yel   +11 more
semanticscholar   +1 more source

Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]

, 2004
86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Darlow, J.M., Farrell, A.M., John M. Darlow, David I. Stott, Stott, D.I., Alex M. Farrell   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source