Results 71 to 80 of about 12,666 (271)

Advances in Membranous Nephropathy

, 2021
International audienceMembranous nephropathy (MN) is a rare auto-immune disease where the glomerulus is targeted by circulating auto-antibodies mostly against podocyte antigens, which results in the formation of electron-dense immune complexes ...
Pierre Ronco, Ronco, Pierre, Hanna Debiec, Plaisier, Emmanuelle, Debiec, Hanna, Emmanuelle Plaisier   +5 more
core   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Clinical implications of pathological features of primary membranous nephropathy [PDF]

BMC Nephrology, 2018
The clinical outcome varies considerably in primary membranous nephropathy (pMN). Risk factors for kidney prognosis include ageing, male gender, persistent heavy proteinuria, decreased eGFR at presentation, persistent elevation of anti-PLA2R antibodies, no remission, and so on.
Xiao-dan Zhang, Zhao Cui, Mu-fan Zhang, Jia Wang, Yi-miao Zhang, Zhen Qu, Xin Wang, Jing Huang, Fang Wang, Li-qiang Meng, Xu-yang Cheng, Su-xia Wang, Gang Liu, Ming-hui Zhao   +13 more
openaire   +3 more sources

THE IMPORTANCE OF GLOMERULAR C3 ACCUMULATION IN ELDERLY PATIENTS WITH PRIMARY MEMBRANOUS NEPHROPATHY

, 2023
Objective: The purpose of this study was to investigate the impact of glomerular C3 accumulation density on clinical, histopathological parameters and outcomes in elderly (>60 years) individuals with primary membranous nephropathy (PMN)
Ozluk, Yasemin, Demir, Erol, Dirim, Ahmet Burak, Mirioglu, Safak, Safak, Seda, Caliskan, Yasar, Oto, Ozgur Akin, Artan, Ayse Serra, Guller, Nurana, Yazici, Halil, Ucar, Ali Riza, Soltanova, Lala, Nuriyev, Kanan   +12 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Morphological changes in kidneys and clinical presentation in patients with primary and secondary membranous nephropathy [PDF]

Srpski Medicinski Časopis Lekarske Komore
Introduction/Aim: Membranous nephropathy (MN) typically presents as nephrotic syndrome and may be idiopathic (primary MN, pMN) or occur secondary to other diseases (secondary MN, sMN).
Milivojević Danijel, Pecić Maja, Nikolić Gorana, Mioljević Ana, Brković Voin, Baralić Marko, Đurić Petar, Janković Aleksandar, Radojević-Škodrić Sanja, Životić Maja   +9 more
doaj   +1 more source

Characterization of novel antigens in membranous nephropathy [PDF]

, 2016
INTRODUCTION: Membranous nephropathy is an autoimmune disease that targets glomeruli of the kidney. Previous discoveries in membranous nephropathy include the discovery of megalin as an antigen in the proximal tubular brush border fraction (Fx1A) and ...
Coles, Paige
core  

Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy

, 2017
G.L. and P.R. contributed equally to this work.International audienceThe phospholipase A2 receptor (PLA2R1) is the major autoantigen in primary membranous nephropathy.
Pierre Ronco, Zaghrini, Christelle, Vincent L.M. Esnault, Ronco, Pierre, Barbara Seitz-Polski, Hanna Debiec, Alexandra Rousseau, Karine Dahan, Payre, Christine, Esnault, Vincent L.M., Seitz-Polski, Barbara, Dahan, Karine, Rousseau, Alexandra, Gérard Lambeau, Christine Payré, Debiec, Hanna, Lambeau, Gérard, Christelle Zaghrini   +17 more
core   +1 more source

Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy

, 2020
Membranous nephropathy is characterized by deposition of immune complexes along the glomerular basement membrane. PLA2R and THSD7A are target antigens in 70% and 1-5% of primary membranous nephropathy cases, respectively.
Jadoul, Michel, Sethi, Sanjeev, Fervenza, Fernando C., Charlesworth, M Cristine, Buob, David, Ronco, Pierre, Charlesworth, M. Cristine, Fervenza, Fernando, Ravindran, Aishwarya, Gross, LouAnn, Madden, Benjamin, Debiec, Hanna, Morelle, Johann   +12 more
core   +1 more source