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Metabolite diagnosis of primary hyperoxaluria type 3

Pediatric Nephrology, 2018
Primary hyperoxaluria type 3 (PH3) is a recently described cause of childhood renal calculi. It results from mutations in the HOGA1 gene and most cases have been diagnosed after clinical ascertainment, exclusion of other genetic hyperoxalurias and mutation testing. Metabolite testing has not been widely applied but holds promise for the rapid screening
Lawrence, Greed   +6 more
openaire   +2 more sources

Microbial production of primary metabolites

Naturwissenschaften, 1980
Microbial production of primary metabolites contributes significantly to the quality of life. Through fermentation, microorganisms growing on inexpensive carbon sources can produce valuable products such as amino acids, nucleotides, organic acids, and vitamins which can be added to food to enhance its flavor or increase its nutritive values.
openaire   +2 more sources

Pharmacological Studies on Perazine and its Primary Metabolites

Pharmacopsychiatry, 1989
The study served to answer the question whether metabolites possibly contribute to the clinical actions of the neuroleptic drug perazine. The primary metabolites demethylperazine and perazine sulfoxide were investigated with regard to influences on behavior in mice, to an antiemetic action in dogs, and to a modification of the pressor effect of ...
U, Brand   +3 more
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Production of Primary and Secondary Metabolites Using Algae

2017
Over the past few decades, there has been an increase in the number of research studies focused on all aspects of the ecology, physiology, biochemistry, cell biology, molecular biology, systematics and uses of algae. This chapter will provide an overview of the potential human health advantages associated with the use of algae as a source of high-value
Rico, Milagros   +5 more
openaire   +2 more sources

Primary metabolites of Phaseolus vulgaris nodules

Phytochemistry, 1978
Abstract More ethanol soluble material (carbohydrate and amino nitrogen) was found in both host cell and bacteroid components of Phaseolus vulgaris nodules from plants grown at 28 W/m2 than from plants grown at 7 W/m2. The range of compounds identified was similar at the two irradiances.
Linda D. Antoniw, Janet I. Sprent
openaire   +1 more source

Extraction of Primary and Secondary Metabolites

2005
Several new methods besides the usual organic solvent extraction have been developed over the last few years for the extraction of primary and secondary metabolites. These are: alcohol extraction with various biocompatible solvents, recovery of carboxylic acids and antibiotics with reactive extraction, dissociation extraction, aqueous two-phase ...
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Methods, applications and concepts of metabolite profiling: Primary metabolism

2007
In the 1990s the concept of a comprehensive analysis of the metabolic complement in biological systems, termed metabolomics or alternately metabonomics, was established as the last of four cornerstones for phenotypic studies in the post-genomic era.
Steinhauser, D., Kopka, J.
openaire   +3 more sources

Vitamin D metabolites and skeletal consequences in primary hyperparathyroidism

Clinical Endocrinology, 2007
SummaryBackground  Primary hyperparathyroidism (PHPT) is associated with reduced bone mineral density (BMD) mainly at sites rich in cortical bone. However, successful parathyroidectomy causes an increase in BMD especially at sites rich in trabecular bone. Plasma 25‐hydroxyvitamin D (25OHD) levels are typically reduced and plasma 1,25‐dihydroxyvitamin D
Moosgaard, Bjarke   +5 more
openaire   +4 more sources

The integrated response of primary metabolites to gene deletions and the environment

Molecular BioSystems, 2012
Abstract Intracellular metabolites arise from the molecular integration of genomic and environmental factors that jointly determine metabolic activity. However, it is not clear how the interplay of genotype, nutrients, growth, and fluxes affect metabolite concentrations globally.
Ewald JC, Matt T, Zamboni N
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Steroid receptor profiling of vinclozolin and its primary metabolites

Toxicology and Applied Pharmacology, 2006
Several pesticides and fungicides commonly used to control agricultural and indoor pests are highly suspected to display endocrine-disrupting effects in animals and humans. Endocrine disruption is mainly caused by the interference of chemicals at the level of steroid receptors: it is now well known that many of these chemicals can display estrogenic ...
José-Manuel, Molina-Molina   +9 more
openaire   +2 more sources

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