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Urinary excretion of MPTP and its primary metabolites in mice
Life Sciences, 1988Mice were injected with single doses of MPTP (15 mg/kg, s.c.) containing one microCi of [3H]methyl-MPTP. Approximately 42% of the total injected [3H] was detected in the urine within 3 hours after drug administration. The early urine samples were analyzed using high pressure liquid chromatography. MPTP N-oxide was identified as a major metabolite, with
Y S, Lau, J M, Crampton, J A, Wilson
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Degradation and Sorption of Metribuzin and Primary Metabolites in a Sandy Soil
Journal of Environment Quality, 2004ABSTRACTLeaching to the ground water of metabolites from the herbicide metribuzin [4‐amino‐6‐(1,1‐dimethylethyl)‐3‐(methylthio)‐1,2,4‐triazin‐5‐one] has been measured in a Danish field experiment in concentrations exceeding the European Union threshold limit for pesticides at 0.1 μg/L. In the present work, degradation and sorption of metribuzin and the
Henriksen, Trine +2 more
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Characterization of Metabolites of Astaxanthin in Primary Cultures of Rat Hepatocytes
Drug Metabolism and Disposition, 1999The metabolism of the nonprovitamin A carotenoid astaxanthin was investigated in primary cultures of rat hepatocytes. In a time course study based on HPLC and gas chromatography-mass spectrometry analyses, one main metabolite, (rac)-3-hydroxy-4-oxo-beta-ionone, was found.
E, Wolz +4 more
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Role of primary metabolites in plant defense against pathogens
Microbial Pathogenesis, 2019Plants under natural environment facing various pathogens, tend to produce defense to maintain their fitness and minimize pathogenic damage. Plant-pathogens interaction is gaining more importance by researches as, their means of the fight are primary metabolites. The ultimate result of either means of defense is pathogenesis or resistance.
Madiha, Zaynab +5 more
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[Recognition and analysis on primary metabolites of nonylphenol].
Huan jing ke xue= Huanjing kexue, 2009In order to discuss the nonylphenol (NP) biodegradability effect in the wastewater treatment process, the primary metabolites and route of NP had been analyzed in the molecular level by the interpretation of gas chromatography mass spectrometry (GC-MS) and the two experimental methods. A method was that activated sludge degraded two types of simulating
Rui-xia, Hao +3 more
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Targeted Metabolomics for Homocysteine-Related Metabolites in Primary Hepatocytes
2014Liquid chromatography-tandem mass spectrometry has become the most convenient method to identify and quantify low molecular weight metabolites from various sources. Metabolomics studies of hepatocytes hold promise for the identification of the mechanisms of toxicant-related disease processes.
Irena, Selicharová, Marek, Kořínek
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Microbial Synthesis of Primary Metabolites
2011Arnold L. Demain, Sergio Sánchez
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