Results 51 to 60 of about 5,320,666 (302)

Exploring Antioxidant and α-Glucosidase Inhibitory Activities in Mulberry Leaves (Morus alba L.) across Growth Stages: A Comprehensive Metabolomic Analysis with Chemometrics

Molecules, 2023
Metabolic product accumulation exhibited variations among mulberry (Morus alba L.) leaves (MLs) at distinct growth stages, and this assessment was conducted using a combination of analytical techniques including high-performance liquid chromatography ...
Wenjie Li, Shenghui Hao, Hengyang Li, Qi An, Lina Yang, Bing Guo, Zijing Xue, Yongli Liu, Long Guo, Yuguang Zheng, Dan Zhang   +10 more
doaj   +1 more source

Acknowledgement to Reviewers of Metabolites in 2015

, 2016
The editors of Metabolites would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015.
Metabolites Editorial Office
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Combined Untargeted and Targeted Fingerprinting by Comprehensive Two-Dimensional Gas Chromatography to Track Compositional Changes on Hazelnut Primary Metabolome during Roasting

Applied Sciences, 2021
This study focuses on the detectable metabolome of high-quality raw hazelnuts (Corylus avellana L.) and on its changes after dry-roasting. Informative fingerprinting was obtained by comprehensive two-dimensional gas chromatography with fast-scanning ...
Marta Cialiè Rosso, Federico Stilo, Carlo Bicchi, Melanie Charron, Ginevra Rosso, Roberto Menta, Stephen E. Reichenbach, Christoph H. Weinert, Carina I. Mack, Sabine E. Kulling, Chiara Cordero   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects of various Agrobacterium rhizogenes strains on hairy root induction and analyses of primary and secondary metabolites in Ocimum basilicum

Frontiers in Plant Science, 2022
The hairy root (HR) culture system is an excellent alternative strategy to the whole plant system for producing valuable compounds. However, selection of suitable Agrobacterium strain for the successful induction of HR is an essential step for enhanced ...
Ramaraj Sathasivam, Minsol Choi, Ramalingam Radhakrishnan, Haejin Kwon, Jiwon Yoon, So Hwi Yang, Jae Kwang Kim, Yong Suk Chung, Sang Un Park, Sang Un Park   +9 more
doaj   +1 more source

Acknowledgement to Reviewers of Metabolites in 2017

, 2018
Peer review is an essential part in the publication process, ensuring that Metabolites maintains high quality standards for its published papers [...
Metabolites Editorial Office, null null
core   +1 more source

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes [PDF]

, 2015
This study was supported by funding from the UK Biotechnology and Biological Sciences Research Council Diet and Health Research Industry Club (BBSRC-DRINC) (BB/I006028/1) and by a studentship grant (BB/J500100/1).Scope: Flavonoids are generally studied ...
Kerr, J.S., Zhang, Q., O'Hagan, David, Kerr, Jason, Kay, C.D., Maria A. O'Connell, Sai Krishna Yalamanchili, Raheem, S., David O'Hagan, Colin D. Kay, O'Connell, M.A., O'Hagan, D., di Gesso, J.L., Kay, Colin, Jason S. Kerr, Saki Raheem, Zhang, Qingzhi, Krishna Yalamanchili, Sai, O’Hagan, D., Di Gesso, Jessica, O'Connell, Maria, Raheem, Saki, Yalamanchili, S.K., Jessica L. di Gesso, Qingzhi Zhang, O'Hagan, D.; id_orcid   +25 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Microalgae-derived bioactive compounds: metabolic potential, extraction strategies, and sustainable applications in food, pharmaceuticals, and animal feed

Applied Phycology
This paper critically reviews how the metabolic potential of microalgae can be harnessed for the food, pharmaceutical, and animal feed industries by integrating cultivation system design with green extraction technologies, emphasizing their combined ...
Ng Jia Xuan, Hizriana Nuril Fitri Herryady, Siti Nur Hazwani Oslan, Sitti Raehanah Muhamad Shaleh, Mohd–Shamzi Mohamed, Asep Awaludin Prihanto, Andi Weri Sompa, Nurul Huda   +7 more
doaj   +1 more source