Results 41 to 50 of about 5,320,666 (302)

Synthesis and μ-Opioid Activity of the Primary Metabolites of Carfentanil. [PDF]

ACS Med Chem Lett, 2019
Carfentanil is a synthetic opioid significantly more potent than clinically prescribed fentanyl. The primary metabolites of carfentanil, generated from human liver microsomes, were structurally confirmed through chemical synthesis. The synthesized compounds were evaluated for μ-opioid receptor (MOR) functional activity.
Hsu FL, Walz AJ, Myslinski JM, Kong L, Feasel MG, Goralski TDP, Rose T, Cooper NJ, Roughley N, Timperley CM.   +9 more
europepmc   +4 more sources

Primary Metabolite Profiling of Tinospora cordifolia

Natural Products Chemistry & Research, 2016
Plants are the sources of many bioactive compounds containing many primary metabolites like, carbohydrates (starch, sugar), proteins, phenols, ascorbic acid etc. are useful for flavoring, fragrances, insecticides, sweeteners and natural dyes (Kaufman).
Abhimanyu Sharma, Amla Batra
openaire   +1 more source

Seasonal Metabolic Investigation in Pomegranate (Punica granatum L.) Highlights the Role of Amino Acids in Genotype- and Organ-Specific Adaptive Responses to Freezing Stress

Frontiers in Plant Science, 2021
Every winter, temperate woody plants have to cope with freezing stress. Winter hardiness is of crucial importance for pomegranate survival and productivity.
Parisa Yazdanpanah, Parisa Yazdanpanah, Parisa Jonoubi, Mehrshad Zeinalabedini, Homa Rajaei, Mohammad Reza Ghaffari, Mohammad Reza Vazifeshenas, Somayeh Abdirad, Somayeh Abdirad   +8 more
doaj   +1 more source

Acknowledgement to Reviewers of Metabolites in 2013

, 2014
The editors of Metabolites would like to express their sincere gratitude to the following reviewers for assessing manuscripts in ...
Metabolites Editorial Office
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Response of Metabolites in Cymbopogon distans Leaves to Water Addition in Karst Areas during Different Seasons

Horticulturae, 2023
Climate change could influence the plant response to drought stress in karst environments. However, fewer related studies have been reported. This study examined the impact of artificial water addition on the accumulation of metabolites of Cymbopogon ...
Aiwei Huang, Hongxia Jing, Muhammad Umair, Hongmei Du   +3 more
doaj   +1 more source

Primary Metabolites, Anthocyanins, and Hydrolyzable Tannins in the Pomegranate Fruit. [PDF]

Front Plant Sci, 2019
Pomegranate (Punica granatum L.) is an important and interesting fruit tree that is cultivated in many parts of the world. In recent years, along with the increase in its cultivation and consumption there has been a dramatic increase in the scientific ...
Bar-Ya'akov I, Tian L, Amir R, Holland D.   +3 more
europepmc   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

QUANTITATIVE ANALYSIS OF PRIMARY AND SECONDARY METABOLITES IN AQUEOUS HOT EXTRACT OF Eugenia unilora (L.)LEAVES. [PDF]

, 2015
Quantitative analysis is very essential for identifying the compounds present in the medicinal plants.In the present study laboratory evaluations were made to quantitatively assess primary metabolites and secondary metabolites in aqueous hot extract of ...
Daniel, Geedhu, Shanmugasundaram, Dr. Krishnakumari   +1 more
core   +1 more source

Network during light-induced cotyledons opening and greening in Astragalus membranaceus

Journal of Plant Interactions, 2020
Opening and greening are main characteristics of morphogenesis of cotyledons. For revealing interrelationship between metabolism and morphogenesis, metabolic shifts were analyzed in cotyledon of A.
Nan Yang, Ye Zhang, Jia Liu, Yang Liu, Qi Chen, Hongzheng Wang, Xiaorui Guo, Werner B. Herppich, Zhonghua Tang   +8 more
doaj   +1 more source