Results 81 to 90 of about 5,320,666 (302)

Percentage of primary oxidative metabolites from deuterated forms of 1a with r-CYP3A4.

, 2018
Percentage of primary oxidative metabolites from deuterated forms of 1a with r-CYP3A4.
Alfin D. N. Vaz (172262), Joseph S. Warmus (1997752), Suvi T. M. Orr (1485076), Kentaro Futatsugi (1399639), David W. Piotrowski (1944802), Angela C. Wolford (2004778), Yinsheng Zhang (321530), Hao Sun (14095), Steven B. Coffey (1463167)   +8 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparative study of compounds of primary exchange duckweed (Lemna minor L.), trisulki duckweed (Lemna trisulca L.) and spirodela (Spirodella polyrrhiza L. Schleid.)

Бюллетень сибирской медицины, 2017
The purpose of the paper is to study qualitative composition and quantitative content of primary exchange compounds in duckweed (Lemna minor L.), trisulki duckweed (Lemna trisulca L.) and spirodela (Spirodella polyrrhiza (L.) Schleid).Materials and ...
L. A. Nikiforov, N. S. Fursa, S. V. Krivoshchekov, V. A. Kurkin, M. V. Belousov   +4 more
doaj   +1 more source

Data_Sheet_1_Comprehensive metabolic analyses provide new insights into primary and secondary metabolites in different tissues of Jianghua Kucha tea (Camellia sinensis var. assamica cv. Jianghua).docx

, 2023
BackgroundJianghua Kucha (JHKC) is a special tea germplasm with enriched specialized secondary metabolites, including theacrine, non-epimeric flavanols and methylated flavanols.
Yong Yuan (253559), Jiqiang Jin (15648959), Zhen Liu (74646), Zhida Chen (2667100), Zhi Lin (281756), Wenliang Wu (568030), Weidong Dai (135643), Jiang Shi (413507), Shuguang Zhang (9707)   +8 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Differentially Colored Photoselective Nets as a Sophisticated Approach to Improve the Agronomic and Fruit Quality Traits of Potted Blueberries

Agronomy
The usage of photoselective anti-hail nets is a modern approach to protect crops from adverse climatic factors with additional beneficial effects on orchard performance.
Jasminka Milivojević, Dragan Radivojević, Ilija Djekić, Slavica Spasojević, Jelena Dragišić Maksimović, Dragica Milosavljević, Vuk Maksimović   +6 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Influence of Wild and Cultivated Environments on the Antioxidant and Medicinal Components of Rhodiola sachalinensis A. Boriss.

Plants
Rhodiola sachalinensis A. Boriss., recognized for its significant medicinal potential, is increasingly threatened by overharvesting in wild habitats.
Xin Wei, Qiu-Yang Chang, Yang Liu, He-Nian Hua, Ya-Nan Liu, Zhong-Hua Tang, Li-Qiang Mu   +6 more
doaj   +1 more source

Untargeted NMR-Based Methodology in the Study of Fruit Metabolites

, 2015
In this review, fundamental aspects of the untargeted NMR-based methodology applied to fruit characterization are described. The strategy to perform the structure elucidation of fruit metabolites is discussed with some examples of spectral assignments by
Antiochia, R., Simone Carradori, Anatoly Petrovich Sobolev, Proietti, N., Luisa Mannina, Capitani, Donatella, Noemi Proietti, Sobolev, Anatoly Petrovich, Daglia, M., Capitani, D., Sobolev, A. P., Riccarda Antiochia, Giusti, A. M., Proietti, Noemi, Maria Daglia, Anatoly Sobolev, Anna Maria Giusti, Mannina, L., Carradori, Simone, Antiochia, Riccarda, Donatella Capitani, Anna Giusti, DAGLIA, MARIA, Proietti Noemi, Sobolev AP, Carradori Simone, Mannina L, Sobolev Anatoly Petrovich, Capitani Donatella, Capitani D, Giusti Anna Maria, Proietti N, Mannina Luisa, Giusti A M, Daglia Maria, Mannina, Luisa, Antiochia Riccarda, Daglia M, Giusti, Anna Maria, Antiochia R, Carradori S   +40 more
core   +1 more source