Results 101 to 110 of about 7,735,427 (345)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. [PDF]
, 1979 M Miettinen +2 more
openalex +1 more source
Primary prevention of dementia
Psychiatry, 2004 Abstract Symptomatic treatments that work by enhancing neurotransmitter function have been available for several years, and are generally accepted as being modestly beneficial in about 50% of those for whom they are prescribed. Disease-modifying drugs that may prevent or retard neuronal deterioration are being developed and some are in early clinical
openaire +3 more sources
Primary Prevention of Heart Failure [PDF]
ISRN Cardiology, 2012 Most heart failure research and quality improvement efforts are targeted at treatment and secondary prevention of patients with manifest heart failure. This is distinct from coronary disease where primary prevention has been a focus for over three decades.
openaire +2 more sources
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
Prevention of Coronary Heart Disease and Stroke (a workbook for primary care teams) [PDF]
, 1988 Lewis Ritchie
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Prospects for the Primary Prevention of Myocardial Infarction and Stroke
Journal of Cardiovascular Pharmacology and Therapeutics, 2018 Cardiovascular disease (CVD), principally myocardial infarction (MI) and stroke, is the leading clinical and public health problem in the United States and is rapidly becoming so worldwide.
Madison Caldwell +4 more
semanticscholar +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Primary Prevention and the Occupational Health Nurse [PDF]
, 1986 Molly J. McCauley
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