Results 101 to 110 of about 7,915,710 (337)

Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study

Scientific Reports, 2018
Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases,
Ka Chun Chong, Chi Zhang, Katherine Min Jia, Benny Chung Ying Zee, Tongyong Luo, Lei Wang, Greta Chun Huen Tam, Riyang Sun, Maggie Haitian Wang, Xuhua Guan   +9 more
doaj   +1 more source

Revisiting the Role of Aspirin for the Primary Prevention of Cardiovascular Disease.

Circulation, 2019
Aspirin is the cornerstone of the antithrombotic management of patients with established atherosclerotic cardiovascular disease, but major guidelines provide conflicting recommendations for its use in primary prevention.
Guillaume Marquis-Gravel, M. Roe, R. Harrington, D. Muñoz, Adrian F. Hernandez, W. Jones   +5 more
semanticscholar   +1 more source

PRIMARY SCHOOL STUDENTS PREVENTION OF SCHOOL MALADJUSTMENT [PDF]

, 2023
Almazhay Kulzhanovna Egenissova, Karas Orzhanyly Kaziyev   +1 more
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease, and for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis and cost-effectiveness analysis.

Health Technology Assessment, 2017
BACKGROUND Warfarin is effective for stroke prevention in atrial fibrillation (AF), but anticoagulation is underused in clinical care. The risk of venous thromboembolic disease during hospitalisation can be reduced by low-molecular-weight heparin (LMWH):
J. Sterne, P. Bodalia, P. Bryden, P. Davies, J. López-López, G. Okoli, H. Thom, D. Caldwell, S. Dias, D. Eaton, J. Higgins, W. Hollingworth, C. Salisbury, J. Savović, R. Sofat, A. Stephens-Boal, N. Welton, A. Hingorani   +17 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Risk Assessment and Anticoagulation for Primary Stroke Prevention in Atrial Fibrillation [PDF]

, 1999
Lalit Kalra, Nicolás Pérez‐Fernández, Anne Melbourn   +2 more
openalex   +1 more source

Primary-level and community worker interventions for the prevention of mental disorders and the promotion of well-being in low- and middle-income countries

, 2021
Marianna Purgato, Jibril Abdulmalik, Eleonora Prina, Caterina Ceccarelli, Wietse A. Tol, Nadja van Ginneken, Eleonora Uphoff, Davide Papola, Francesco Amaddeo, Rachel Churchill, Mark J. D. Jordans, Crick Lund, Corrado Barbui   +12 more
openalex   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source