Results 91 to 100 of about 9,316,170 (262)

Protocol for the saMS trial (supportive adjustment for multiple sclerosis): a randomized controlled trial comparing cognitive behavioral therapy to supportive listening for adjustment to multiple sclerosis [PDF]

, 2009
BackgroundMultiple Sclerosis (MS) is an incurable, chronic, potentially progressive and unpredictable disease of the central nervous system. The disease produces a range of unpleasant and debilitating symptoms, which can have a profound impact including ...
McCrone Paul, Roche Suzanne, Dennison Laura, Sabine Landau, Moss-Morris, Rona, Trudie Chalder, Chalder, Trudie, Moss-Morris Rona, Lucy Yardley, Chalder Trudie, Roche, Suzanne, Yardley, Lucy, Suzanne Roche, McCrone, Paul, Yardley Lucy, Landau, Sabine; id_orcid, Chalder, Trudie; id_orcid, Landau, Sabine, Laura Dennison, Dennison, Laura, Paul McCrone, Landau Sabine, Rona Moss-Morris   +22 more
core   +2 more sources

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Fluoxetine as disease modifying treatment in multiple sclerosis : rationale, evaluation of the use of MRI to monitor treatment, and preliminary findings [PDF]

, 2009
Patients with multiple sclerosis (MS) lack astrocytic β2-adrenergic receptors and this may contribute to the focal inflammatory demyelinating lesions and axonal degeneration that characterize this disease.
Mostert, Jop Pieter,, Mostert, Jop Pieter   +1 more
core   +16 more sources

A grounded theory analysis of the occupational impact of caring for a partner who has multiple sclerosis [PDF]

, 2006
Chronic progressive conditions such as multiple sclerosis impact engagement in and orchestration of daily occupations by people with the condition, and their family members.
Molineaux, M, Molineux, Matthew, Heward, Kate, Heward, K, Gough, B, Gough, B., Gough, Brendan, Heward, K.   +7 more
core   +1 more source

Anti‐CD20 Discontinuation Versus Continuation in People Aged Over 50 With Non‐Active Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether discontinuing anti‐CD20 therapy in people with relapsing‐onset MS aged over 50 is associated with an increased risk of relapse, inflammatory activity, confirmed disability accrual, and serious infection compared with continuing therapy.
Alexia Moukhine, Fabien Rollot, Romain Casey, Nicolas Collongues, Sandra Vukusic, Guillaume Mathey, Anne Laure Dubessy, Jonathan Ciron, Jérôme De Seze, Aurélie Ruet, Pierre Labauge, Arnaud Kwiatkowski, Hélène Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun‐Frenay, David Axel Laplaud, Eric Berger, Eric Thouvenot, Jean Pelletier, Abdullatif Al Khedr, Olivier Casez, Bertrand Bourre, Abir Wahab, Laurent Magy, Jean‐Philippe Camdessanché, Ines Doghri, Solène Moulin, Mariana Sarov Rivière, Karolina Hankiewicz, Amélie Dos Santos, Corinne Pottier, Eric Manchon, Jennifer Aboab, Maia Tchikviladze, Thomas David, Gilles Edan, Emmanuelle Le Page, Laure Michel, Anne Kerbrat, OFSEP Investigators   +40 more
wiley   +1 more source

Examining the link between information processing speed and executive functioning in multiple sclerosis [PDF]

, 2009
Slowed information processing speed (IPS) is frequently reported in those with multiple sclerosis (MS), and at least 20% are compromised on some aspect of executive functioning also.
Drew, Margaret A., Margaret A. Drew, Nicola J. Starkey, Robert B. Isler, Starkey, Nicola J., Isler, Robert B.   +5 more
core   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

Risk of fractures in patients with multiple sclerosis: a population-based cohort study. [PDF]

, 2012
OBJECTIVE: To examine the risk of fracture in patients with multiple sclerosis (MS) compared with population-based controls. METHODS: A population-based cohort study was performed in the Dutch PHARMO Record Linkage System (1998-2008). Patients with MS (n
Van Staa, Tjeerd; id_orcid, Uitdehaag, BMJ, van Staa, T.P., Vries, F. de, van Staa, TP, Vestergaard, P, Herings, R.M., Leufkens, HGM, de Vries, F, Herings, RM, Staa, TP van, Uitdehaag, B M J, Herings, R M C, Leufkens, H.G.M., Uitdehaag, B.M.J., Cooper, Cyrus, van Staa, Tjeerd P., Herings, Ron M. C., Leufkens, H.G., Bazelier, MT, Dobson, R, Uitdehaag, Bernard M. J., Bazelier, M.T., Leufkens, H G M, Leufkens, HG, Ramagopalan, S, Cooper, C., Herings, R.M.C., Leufkens, Hubertus G. M., Cooper, C, Uitdehaag, BM, Bazelier, M T, de Vries, F., van Staa, T-P, Vestergaard, P., Herings, RMC, Giovannoni, G, Bazelier, Marloes T., Uitdehaag, B.M., de Vries, F.; id_orcid   +39 more
core   +2 more sources

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source