Results 111 to 120 of about 9,316,170 (262)

Assessment of ocrelizumab impact on neurofilament levels in multiple sclerosis patients

Romanian Journal of Laboratory Medicine
Multiple sclerosis (MS) is a debilitating neurological disease characterized by inflammation, demyelination, and neurodegeneration in the central nervous system. Despite extensive research, the pathology of MS remains incompletely understood. Ocrelizumab
Maier Smaranda, Huțanu Adina, Bărcuțean Laura, Sărmășan Emanuela, Bălașa Rodica   +4 more
doaj   +1 more source

Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis.

, 2013
Background: It is unclear if all patients with relapsing remitting multiple sclerosis (RRMS) ultimately develop progressive MS. Onset of progressive disease course seems to be age- rather than disease duration-dependent. Some forms of progressive MS (e.g.
Weinshenker, Brian G., Tang, Junger, Atkinson, Elizabeth J., Kale, Nilufer, Lucchinetti, Claudia F., Kantarci, Orhun H., Siva, Aksel, Abou Zeid, Nuhad, Keegan, B. Mark, Crusan, Daniel J., Tutuncu, Melih, Pirko, Istvan, Noseworthy, John H., Rodriguez, Moses, Pittock, Sean J.   +14 more
core   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Infusion anti-B-cell therapy in multiple sclerosis: a comparative analysis of agents within the same class

Неврология, нейропсихиатрия, психосоматика
Given the recent trends and accumulating evidence supporting the advantages of anti-B-cell therapy, early initiation of this treatment modality in multiple sclerosis (MS) has become increasingly relevant for controlling disease activity and reducing the ...
A. N. Boyko, A. D. Kukushkina, S. V. Rogovsky   +2 more
doaj  

Assessment and optimisation of MRI measures of atrophy as potential markers of disease progression in multiple sclerosis [PDF]

, 2008
There is a need for sensitive measures of disease progression in multiple sclerosis (MS) to monitor treatment effects and understand disease evolution. MRI measures of brain atrophy have been proposed for this purpose. This thesis investigates a number
Anderson, V.
core  

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

The effectiveness of combining a home-based Digital motor Telerehabilitation program with conventional therapy in progressive multiple sclerosis: A study protocol for a multicenter, randomized controlled trial

Digital Health
Objective The primary aim is to evaluate the effectiveness of in-hospital rehabilitation followed by a home-based Digital Telerehabilitation program on mobility versus in-hospital rehabilitation alone in patients with Progressive Multiple Sclerosis ...
Marialuisa Gandolfi, Mauro Crestani, Gabriele Perachiotti, Francesca Salaorni, Andrea Baroni, Alberto Gajofatto, Riccardo Orlandi, Michela Rimondini, Valeria Donisi, Stefano Landi, Giovanni Morone, Mirta Fiorio, Irene Lozzi, Nicola Valè, Ilaria Siviero, Silvia Francesca Storti, Nicola Smania, Sofia Straudi   +17 more
doaj   +1 more source

The Effects of In-Phase Bilateral Upper-Limb Exercises on Corticospinal Plasticity in People with Progressive Multiple Sclerosis: A Pilot Randomized Single-Case Concurrent Multiple-Baseline Design

Brain Sciences
Background: Corticospinal plasticity is impaired in MS. In-phase bilateral upper-limb exercises have been shown to improve corticospinal excitability in people with relapsing-remitting multiple sclerosis, but there is limited literature that supports the
Marinos Chatzikonstantinou, Kyriaki Michailidou, Marios Pantzaris, Gavriella Alexandrou, Charalambos C. Charalambous, Dimitris Sokratous   +5 more
doaj   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source