Results 41 to 50 of about 9,316,170 (262)

Patterns of care for Multiple Sclerosis in a setting of universal care access: A cross-sectional study [PDF]

, 2019
BACKGROUND Current guidelines recommend regular neurological MS care in persons diagnosed with MS, but little is known about implementation of this recommendation or potential access barriers.
Rodgers, S., Kaufmann, Marco; https://orcid.org/, Kuhle, J., Puhan, M.A., Puhan, Milo A, Kuhle, Jens, Puhan, M. A., Kamm, Christian P, Kesselring, Jürg, Rodgers, Stephanie, Pot, Caroline, von Wyl, Viktor, Czaplinski, Adam, Barin, L., Kamm, C.P., von Wyl, V., Barin, Laura, Salmen, A., Ajdacic-Gross, Vladeta, Pot, C., Salmen, Anke, Kaufmann, M., Chan, A., Czaplinski, A., Kamm, Christian P., Swiss Multiple Sclerosis Registry, Chan, Andrew, Gobbi, C., Ajdacic-Gross, V., Gobbi, Claudio, Kesselring, J.   +30 more
core   +1 more source

Symptomatic Therapy and Rehabilitation in Primary Progressive Multiple Sclerosis

Neurology Research International, 2011
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system and a major cause of chronic neurological disability in young adults.
Fary Khan, Bhasker Amatya, Lynne Turner-Stokes   +2 more
doaj   +1 more source

Consensus recommendations for the diagnosis and treatment of multiple sclerosis: 2019 revisions to the MENACTRIMS guidelines [PDF]

, 2020
With evolving diagnostic criteria and the advent of new oral and parenteral therapies for MS, most current diagnostic and treatment algorithms need revision and updating.
Almahdawi, Akram M., Dahdaleh, Maurice P., Alsaadi, Taoufik M., Inshasi, Jihad Said, Yamout, Bassem I., Bohlega, Saeed A., Al-Jumah, Mohammed A., Alsharoqi, Isa Ahmed, Koussa, Salam F., AlKhawajah, Mona Marwan, Al Khaburi, J., Alroughani, Raed A., Goueider, Riyad, Khoury, Samia J., Sahraian, Mohammad Ali, Daodi, S., Slassi, E., Zakaria, Magd Fouad, Hashem, Saher S.   +18 more
core   +1 more source

Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised controlled trial [PDF]

, 2022
Magnetic resonance imaging; Neurofilament light; Secondary progressive multiple sclerosisImatge per ressonància magnètica; Llum del neurofilament; Esclerosi múltiple secundària progressivaImagen por resonancia magnética; Luz de neurofilamento; Esclerosis
Doshi, Anisha, Binks, Sophie, Eshaghi, Arman, Tur Gomez, Carmen, Williams, Thomas, Chan, Dennis   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Experience of Identity Change in People Who Reported a Diagnosis of Multiple Sclerosis : A Qualitative Inquiry [PDF]

, 2019
Background: A diagnosis of multiple sclerosis (MS) can lead to changes to a person’s sense of self. The aim of this study was to investigate the subjective experience of identity change and subsequent adjustment to MS.
das Nair, Roshan, Smale, Kathryn, Lincoln, NB, Lincoln, Nadina B., Barker, AB, Hunt, N, Smale, K., das Nair, R, Hunt, Nigel, Barker, Alexander B., Barker, A., Smale, K, Lincoln, N.B., Hunt, N.   +13 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Primary Progressive Multiple Sclerosis Under Anti-TNFα Treatment: A Case Report

Journal of Central Nervous System Disease, 2020
Antagonists of tumour necrosis factor α (TNFα) are a common therapeutic choice for autoimmune diseases. Although they are effective and relatively safe, an increasing number of immune-mediated adverse events have been reported.
Aniello Iovino, Francesco Aruta, Raffaele Dubbioso, Lucia Ruggiero, Stefano Tozza, Emanuele Spina, Fiore Manganelli, Rosa Iodice   +7 more
doaj   +1 more source