Results 41 to 50 of about 18,969,277 (233)

Youth creativity in arts based interventions guided by the 7Cs model of positive youth development

Discover Education
This study introduces a critical interpretive systematic review that examines how arts-based interventions contribute to adolescent and youth development when interpreted through the expanded 7Cs model of Positive Youth Development (PYD).
Maria Assariotaki, Eleni Vasilaki, Aikaterini Vasiou   +2 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Problem-Oriented Learning Family Models on Decision-Making Skills in Indonesia

Jurnal Pedagogi dan Pembelajaran
Decision-making skills are an essential competency in education but remain challenging to develop effectively through problem-based learning models in Indonesia.
Umalihayati, Laksmi Evasufi Widi Fajari, Ratna Hidayah, Kurniati Rahmadani, Novita Sari   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Development of integrated science instructional materials using Rowntree model to promote 21st century ecoliteracy

Research and Development in Education
The 4.0 Revolution and 21st-century challenges necessitate an education system that integrates 4C skills (Critical Thinking, Communication, Collaboration, and Creativity) with environmental awareness.
Azmi Al Bahij, Julia Anis Handayani, Apri Utami Parta Santi, Erna Yayuk   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Effectiveness of Modified Children’s Songs as a Teaching Tool in Indonesian Language Instruction for Expanding the Vocabulary of Elementary School Students

Mimbar Ilmu
Indonesian language learning in elementary schools still faces challenges in students’ mastery of new vocabulary due to the limited use of engaging learning media that suit students’ characteristics.
Febi Hauliya, Maria Goreti Rini Kristiantari, Anak Agung Ayu Dewi Sutyaningsih   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Ethnosocial-Based Differentiated Digital Learning Model to Enhance Nationalistic Insight

Open Education Studies
The low level of nationality awareness among primary school students, which resulted from inadequate learning, served as the research basis. A learning model was developed to facilitate this, namely the ethnosocial-based differentiated digital learning ...
Asnawi, Kenedi Ary Kiswanto, Sahudra Tengku Muhammad, Ramadhani Dini, Fransyaigu Ronald, Mardin Asna, Arwin   +6 more
doaj   +1 more source

Ethno-Design-Based Learning Tools to Enhance Students' Future Thinking

Journal for Lesson and Learning Studies
The ability to think about the future is one of the important 21st century competencies that needs to be developed in elementary school students to face dynamic global challenges. However, the implementation of learning in elementary schools still tends
Putu Okta Satriani, I Wayan Widiana, I Wayan Ardana   +2 more
doaj   +1 more source