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DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source

The Effectiveness of Modified Children’s Songs as a Teaching Tool in Indonesian Language Instruction for Expanding the Vocabulary of Elementary School Students

Mimbar Ilmu
Indonesian language learning in elementary schools still faces challenges in students’ mastery of new vocabulary due to the limited use of engaging learning media that suit students’ characteristics.
Febi Hauliya +2 more
doaj +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source

Ethno-Design-Based Learning Tools to Enhance Students' Future Thinking

Journal for Lesson and Learning Studies
The ability to think about the future is one of the important 21st century competencies that needs to be developed in elementary school students to face dynamic global challenges. However, the implementation of learning in elementary schools still tends
Putu Okta Satriani, I Wayan Widiana, I Wayan Ardana +2 more
doaj +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source

Primary School Children with Special Education Needs

Психологическая наука и образование (2007. Online), 2016
The paper analyses the modern situation of development in elementary school children. As it is shown, children with special educational needs display a delay in social maturation.
Gavrilushkina O.P., , Egorova M.A.,
doaj +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source

Technology ıntegration in pedagogical processes: digital competence and teaching practices of primary school teachers in Turkey

Discover Education
This study provides a critical and contextual analysis of technology integration and digital transformation in education by examining classroom teachers’ perceptions of digital competencies and their application in pedagogical processes.
Zeliha Alptekin, Ahu Taneri
doaj +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source

Processing Speed throughout Primary School Education: Evidence from a Cross-Country Longitudinal Study. [PDF]

Behav Sci (Basel), 2023
Tikhomirova T, Kuzmina Y, Malykh A, Malykh S. +3 more
europepmc +1 more source

primary education