Results 71 to 80 of about 3,779,032 (314)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

ANALISIS KURIKULUM PENDIDIKAN LINGKUNGAN HIDUP PADA SEKOLAH DASAR PEKANBARU

Primary: Jurnal Pendidikan Guru Sekolah Dasar, 2013
The purpose of this research is that to create even distribution and understanding about life areaeducation to primary school students that will obtain students’ attitudes in doing actionsappropriating to the concept of life area education and create an ...
Mahmud Alpusari
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Current health status of primary school students: a literature review

Фундаментальная и клиническая медицина
Aim. To assess the health status of primary school stu­dents by the literature review and to analyze current direc­tions in the prevention and treatment of their diseases.Ma­terials and Methods.
N. V. Tapeshkina, K. А. Zakharenkova, L. V. Popkova, L. P. Pochueva, O. P. Vlasova, E. M. Sitnikova   +5 more
doaj   +1 more source

Processing Speed throughout Primary School Education: Evidence from a Cross-Country Longitudinal Study. [PDF]

Behav Sci (Basel), 2023
Tikhomirova T, Kuzmina Y, Malykh A, Malykh S.   +3 more
europepmc   +1 more source

Sex Education in Primary Schools?

The New Zealand Annual Review of Education, 2002
The introduction of sex education into primary schools in New Zealand was a controversial and contested issue throughout the 1960s and 1970s. This article explores key documents and legislation produced during the period. It is argued that the controversy surrounding sex education for primary students resulted in the implementation in the 1980s of a ...
openaire   +2 more sources

Teaching science and technology at primary school level: theoretical and practical considerations for primary school teachers' professional training. [PDF]

, 2010
This paper focuses on the importance of starting science and technology education at a young age and at the consequential importance of providing primary school teachers with enough professional background to be able to effectively incorporate science ...
Aalderen-Smeets, Sandra I. van, Asma, Lieke J.F., Walma van der Molen, Juliëtte H.   +2 more
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Food, nutrition and sustainability education in Australian primary schools: a cross-sectional analysis of teacher perspectives and practices

Archives of Public Health
Background Healthy eating patterns from sustainable food systems are crucial for population and planetary health. Primary schools are opportune settings for teaching children about food, nutrition and sustainability (FNS) though little is known about the
Jessica V Kempler, Claire Margerison, Janandani Nanayakkara, Alison Booth   +3 more
doaj   +1 more source

The development of mathematics anxiety as a process of appraisal

Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας
Research on the coping strategies that prospective primary teachers (PPTs) employ when facing stressful life events (LEs) related to mathematics remains limited, and current models of mathematics anxiety do not sufficiently explain how such events—when ...
Eleni Vasilaki, Marinos Anastasakis
doaj   +1 more source