Results 61 to 70 of about 3,779,032 (314)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Alternative approaches to education provision for out-of-school youth in Malawi:The case of Complementary Basic Education [PDF]
, 2012 Young people in Malawi face many challenges. Primary education is struggling with poor internal efficiency, low quality and poor educational outcomes. Access to post-primary education is limited and highly selective. The majority of young people who exit
Jere, Catherine M.
core
Motivation in physical education across the primary-secondary school transition [PDF]
, 2008 The purpose of this study was to examine the temporal patterns of approach-avoidance achievement goals, implicit theories of ability and perceived competence in physical education across the transition from primary to secondary school.
Biddle, S.J.H., +12 more
core +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Primary School Children with Special Education Needs
Психологическая наука и образование (2007. Online), 2016 The paper analyses the modern situation of development in elementary school children. As it is shown, children with special educational needs display a delay in social maturation.
Gavrilushkina O.P., , Egorova M.A.,
doaj +1 more source
Environmental Education should go further [PDF]
, 2000 Outlines Scottish national policy guidelines on 'education for sustainable development' (environmental education for ages 5-14) and implications for primary schools. Describes a 2-year project in which a research team helped staff at an elementary school
Laing, Moira, McNaughton, Marie Jeanne
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Discover EducationThis study provides a critical and contextual analysis of technology integration and digital transformation in education by examining classroom teachers’ perceptions of digital competencies and their application in pedagogical processes.
Zeliha Alptekin, Ahu Taneri
doaj +1 more source
Sex education should begin in primary school
BMJ, 1999 EDITOR—We read with interest the news story about the ChildLine report in which children expressed concerns about puberty.1 We were especially concerned about the dearth of information and support provided by the children's parents. During the past century, there has been an acceleration in the rate of physical growthof children and adolescents ...
O, Ejidokun +3 more
openaire +3 more sources