Results 121 to 130 of about 429,268 (290)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Education and Training in the Cayman Islands: A Partially Annotated Bibliography [PDF]

, 2004
This bibliography on “Education and Training in the Cayman Islands” has been specifically prepared for the UWI School of Continuing Studies’ Cayman Islands Conference.
Quamina-Aiyejina, Lynda
core  

A scoping review on early childhood caries and inequalities using the Sustainable Development Goal 10 framework

BMC Oral Health
Background Social inequalities contribute to health disparities. This study aimed to map evidence on early childhood caries (ECC) related to the United Nations' Sustainable Development Goal 10 (SDG 10).
Morẹ́nikẹ́ Oluwátóyìn Foláyan, Elisa Maria Rosa de Barros Coelho, Carlos Alberto Feldens, Balgis Gaffar, Jorma I. Virtanen, Olunike Rebecca Abodunrin, Duangporn Duangthip, Ola B. Al-Batayneh, Ana Vukovic, Maha El Tantawi, Robert J. Schroth   +10 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

A suggested programme for developing 4th year primary pupils’ performance in Mathematical word problems in Kuwait [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The main objective of this study was to investigate the effect of using a suggested mathematical word-problem training programme on Primary 4 pupils ...
Almansouri, Meshal B
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Change and continuity in school practice: A study of the influences affecting secondary school teachers' work, and of the role of local and national policies within them [PDF]

, 1991
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis examines the impact of local and national education policies on teachers' practice in six secondary schools in two similar, non-contiguous ...
Bennett, Nigel David
core  

Key Program Outcomes for K-12 School Gardens Identified Through Expert Consensus

EDIS, 2018
National trends indicate that school gardens are positioned to become fixtures in primary and secondary education.  Garden-based learning and curricula are aligned with school standards and reinforce educational activities in diverse subjects, including
Susan Webb, John M. Diaz, Catherine G. Campbell   +2 more
doaj  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source