Results 101 to 110 of about 7,584,855 (293)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Hospitalization of Field Museum
, 1918 Memorandum specification completed by the architectural firm Graham, Anderson, Probst and White for the trustees of the Field Museum. The specification was developed to outline the construction and finishing work for converting the existing ...
Graham, Anderson, Probst and White
core
Formal Verification, Integration and Physical Evaluation of Prime-Field Masking on Silicon
Transactions on Cryptographic Hardware and Embedded SystemsThe resistance of provably secure masked circuits to physical attacks depends in part on the underlying algebraic group and recombination function. Masking over finite fields of odd prime order has been demonstrated, both in theory and in practice, to ...
Gaëtan Cassiers +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Optimization of Prime Editing System and Its Application in Large DNA Fragment Editing
Shengwu huaxue yu shengwu wuli jinzhanGene editing technology utilizes artificial nucleases to insert, replace, or delete specific sequences in desired genomic regions. The discovery of CRISPR/Cas9 nucleases was a milestone in the development of advanced gene editing tools, which ...
JIAO Yao-Ge, YAO Shao-Hua
doaj +1 more source
Constacyclic codes over finite local Frobenius non-chain rings of length 5 and nilpotency index 4
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2020 The family of finite local Frobenius non-chain rings of length 5 and nilpotency index 4 is determined, as a by-product all finite local Frobenius non-chain rings with p5 elements (p a prime) and nilpotency index 4 are given.
Castillo-Guillén C. A. +1 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source