Results 111 to 120 of about 7,584,855 (293)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Ultradiffuse Galaxies—A Distinct Population? Dwarf Galaxies in the Coma Cluster and A262 from Deep u′–g′–r′ Wendelstein Imaging Data

The Astrophysical Journal Supplement Series
In this study, we compare the structural parameters of ultradiffuse galaxies (UDGs) to those of other dwarf galaxies and investigate whether UDGs form a distinct population.
Raphael Zöller, Matthias Kluge, Benjamin Staiger, Ralf Bender   +3 more
doaj   +1 more source

Improvements to the number field sieve for non-prime finite fields

CoRR, 2014
We propose various strategies for improving the computation of discrete logarithms in non-prime fields of medium to large characteristic using the Number Field Sieve. This includes new methods for selecting the polynomials; the use of explicit automorphisms; explicit computations in the number fields; and prediction that some units have a zero virtual ...
Barbulescu, Razvan, Gaudry, Pierrick, Guillevic, Aurore, Morain, François   +3 more
openaire   +3 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

How to support experiments : a guide for the mentors

, 2019
We Finns are a nation of planners. We are good at thinking about how things should be done, but we often lack the courage to see our plans through. In a world full of complex challenges, solutions born on the designer’s table alone will not work. That is

core  

Phase-diagram of condensed and isolated skyrmions in chiral magnetic films

Communications Physics
Skyrmions in chiral magnetic films exist either in the isolated phase, confined within the sample, or the condensed phase, occupying it entirely. The stability of magnetic structures in generic perpendicularly magnetized chiral magnetic films is fully ...
Moditha Viraj Wijethunga, Xuchong Hu, Xiangrong Wang   +2 more
doaj   +1 more source

Irrigation Schedule of Rice Based on CROPWAT Model in Southern Central Yunnan

Renmin Zhujiang, 2022
This study is conducted to further review the rationality of the standard for rice irrigation quotas in Jianshui of southern central Yunnan.On the basis of the observation data of Jianshui Meteorological Station from 1958 to 2013 and the rice-season test
DUAN Qicai, WANG Shupeng, ZHANG Lei, LUO Yingpei, QI Na   +4 more
doaj  

Analysis of the Channel Influence to Power Line Communications Based on ITU-T G.9904 (PRIME)

Energies, 2016
ITU-T G.9904 standard, also known as PoweRline Intelligent Metering Evolution (PRIME), is a Power Line Communications standard for advanced metering, grid control and asset monitoring defined by the International Telecommunication Union (ITU).
Asier Llano, Itziar Angulo, Pablo Angueira, Txetxu Arzuaga, David de la Vega   +4 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source