Results 111 to 120 of about 10,903,755 (367)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Irrigation Schedule of Rice Based on CROPWAT Model in Southern Central Yunnan

Renmin Zhujiang, 2022
This study is conducted to further review the rationality of the standard for rice irrigation quotas in Jianshui of southern central Yunnan.On the basis of the observation data of Jianshui Meteorological Station from 1958 to 2013 and the rice-season test
DUAN Qicai, WANG Shupeng, ZHANG Lei, LUO Yingpei, QI Na   +4 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analysis of the Channel Influence to Power Line Communications Based on ITU-T G.9904 (PRIME)

Energies, 2016
ITU-T G.9904 standard, also known as PoweRline Intelligent Metering Evolution (PRIME), is a Power Line Communications standard for advanced metering, grid control and asset monitoring defined by the International Telecommunication Union (ITU).
Asier Llano, Itziar Angulo, Pablo Angueira, Txetxu Arzuaga, David de la Vega   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Ultradiffuse Galaxies—A Distinct Population? Dwarf Galaxies in the Coma Cluster and A262 from Deep u′–g′–r′ Wendelstein Imaging Data

The Astrophysical Journal Supplement Series
In this study, we compare the structural parameters of ultradiffuse galaxies (UDGs) to those of other dwarf galaxies and investigate whether UDGs form a distinct population.
Raphael Zöller, Matthias Kluge, Benjamin Staiger, Ralf Bender   +3 more
doaj   +1 more source

A Hardware-Accelerated ECDLP with High-Performance Modular Multiplication

International Journal of Reconfigurable Computing, 2012
Elliptic curve cryptography (ECC) has become a popular public key cryptography standard. The security of ECC is due to the difficulty of solving the elliptic curve discrete logarithm problem (ECDLP).
Lyndon Judge, Suvarna Mane, Patrick Schaumont   +2 more
doaj   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Phase-diagram of condensed and isolated skyrmions in chiral magnetic films

Communications Physics
Skyrmions in chiral magnetic films exist either in the isolated phase, confined within the sample, or the condensed phase, occupying it entirely. The stability of magnetic structures in generic perpendicularly magnetized chiral magnetic films is fully ...
Moditha Viraj Wijethunga, Xuchong Hu, Xiangrong Wang   +2 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source