Results 121 to 130 of about 9,843,422 (355)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

An analogue of the prime number theorem for finite fields [PDF]

open access: yesarXiv, 2013
We prove an analogue of the prime number theorem for finite fields.
arxiv  

Irregularities in the distributions of primes in function fields

open access: yesJournal of Number Theory, 2008
AbstractWe adapt the Maier matrix method to the polynomial ring Fq[t], and prove analogues of results of Maier [H. Maier, Primes in short intervals, Michigan Math. J. 32 (1985) 221–225] and Shiu [D.K.L. Shiu, Strings of congruent primes, J. London Math. Soc. 61 (2000) 359–373] concerning the distribution of primes in short intervals.
openaire   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

All unitary perfect polynomials over $F_2$ with less than five distinct prime factors [PDF]

open access: yesarXiv, 2010
We find all unitary perfect polynomials over the prime field $\F_2$ with less than five distinct prime factors.
arxiv  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

A Hardware-Accelerated ECDLP with High-Performance Modular Multiplication

open access: yesInternational Journal of Reconfigurable Computing, 2012
Elliptic curve cryptography (ECC) has become a popular public key cryptography standard. The security of ECC is due to the difficulty of solving the elliptic curve discrete logarithm problem (ECDLP).
Lyndon Judge   +2 more
doaj   +1 more source

Analysis of the Channel Influence to Power Line Communications Based on ITU-T G.9904 (PRIME)

open access: yesEnergies, 2016
ITU-T G.9904 standard, also known as PoweRline Intelligent Metering Evolution (PRIME), is a Power Line Communications standard for advanced metering, grid control and asset monitoring defined by the International Telecommunication Union (ITU).
Asier Llano   +4 more
doaj   +1 more source

Function field analogues of Bang-Zsigmondy's theorem and Feit's theorem [PDF]

open access: yesarXiv, 2015
In the number field context, Bang-Zsigmondy's theorem states that for any integers $u, m > 1$, there exists a prime divisor $p$ of $u^m - 1$ such that $p$ does not divide $u^n - 1$ for every integer $0 < n < m$ except in some exceptional cases that can be explicitly determined. A prime $p$ satisfying the conditions in Bang-Zsigmondy's theorem is called
arxiv  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

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