Results 71 to 80 of about 145,218 (264)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Sequences in finite fields yielding divisors of Mersenne, Fermat and Lehmer numbers, II [PDF]

Notes on Number Theory and Discrete Mathematics
Let ρ be an odd prime ≥ 11. In Part I, starting from an M-cycle in a finite field 𝔽_ρ, we have established how the divisors of Mersenne, Fermat and Lehmer numbers arise.
A. M. S. Ramasamy
doaj   +1 more source

Primes in quadratic fields

, 2010
This paper presents algorithms for calculating the quadratic character and the norms of prime ideals in the ring of integers of any quadratic field. The norms of prime ideals are obtained by means of a sieve algorithm using the quadratic character for the field considered.
openaire   +2 more sources

Mersenne Primes in Real Quadratic Fields

, 2012
The concept of Mersenne primes is studied in real quadratic fields of class number 1. Computational results are given. The field $Q(\sqrt{2})$ is studied in detail with a focus on representing Mersenne primes in the form $x^{2}+7y^{2}$. It is also proved that $x$ is divisible by 8 and $y\equiv \pm3\pmod{8}$ generalizing the result of F Lemmermeyer ...
Palimar, Sushma, Shankar, B. R.
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The graph of the square mapping on the prime fields

Discrete Mathematics, 1996
Let \(f: G\to G\) be a map of a finite set into itself. Then \(\text{graph}(G)\) is defined to be the directed graph whose vertices are the elements of \(G\) with a directed edge from \(x\) to \(f(x)\) for all \(x\in G\). In this paper, the action of the map \(f(x)= x^2\) on the multiplicative groups \(F^*_p\) of the prime fields is examined. Let \(C_m\
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Malaphoric $$Z^\prime $$ Z ′ models for $$b \rightarrow s \ell ^+ \ell ^-$$ b → s ℓ + ℓ - anomalies

European Physical Journal C: Particles and Fields
We study some phenomenological effects of kinetic mixing between the hypercharge field and a new U(1) gauge field in specific $$Z^\prime $$ Z ′ models that ameliorate the tensions between measurements and Standard Model predictions in $$b \rightarrow s ...
Ben Allanach, Nico Gubernari
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source