Procedures of data merging in precision cancer medicine: the PRIME-ROSE project. [PDF]
Van der Pol H +22 more
europepmc +1 more source
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
PRIME: an interpretable artificial intelligence model based on liquid biopsy improves prediction of progression risk in non-small cell lung cancer. [PDF]
Wang Y +9 more
europepmc +1 more source
The number of prime divisors of certain Mersenne numbers [PDF]
John R. Ehrman
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Prime mass amino acids: A new numbers based classification of significance to mass spectrometry and protein biology. [PDF]
Downard KM.
europepmc +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Multiverse simulation to explore the impact of analytical choices on type I and type II errors in a reaction time study. [PDF]
Bognar M +6 more
europepmc +1 more source
An Efficient Algorithm for Sorting and Duplicate Elimination by Using Logarithmic Prime Numbers [PDF]
Wei‐Chang Yeh, Majid Forghani-elahabad
openalex +1 more source

