Results 91 to 100 of about 115,699 (314)
Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
Derivation Requirements on Prime Near-Rings for Commutative Rings
Jurnal Ilmu Dasar, 2019 Near-ring is an extension of ring without having to fulfill a commutative of the addition operations and left distributive of the addition and multiplication operations It has been found that some theorems related to a prime near-rings are commutative ...
Dian Winda Setyawati +2 more
doaj +1 more source
Infinite prime avoidance [PDF]
arXiv, 2017 We investigate prime avoidance for an arbitrary set of prime ideals in a commutative ring. Various necessary and/or sufficient conditions for prime avoidance are given, which yield natural classes of infinite sets of primes that satisfy prime avoidance. Examples and counterexamples are given throughout to illustrate the phenomena that can occur.
arxiv
On weakly $1$-absorbing prime ideals of commutative rings [PDF]
arXiv, 2021 Let $R$ be a commutative ring with identity. In this paper, we introduce the concept of weakly $1$-absorbing prime ideals which is a generalization of weakly prime ideals. A proper ideal $I$ of $R$ is called weakly $1$-absorbing prime if for all nonunit elements $a,b,c \in R$ such that $0\neq abc \in I$, then either $ab \in I$ or $c \in I$. A number of
arxiv
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Soft prime and semiprime int-ideals of a ring
AIMS Mathematics, 2020 In this paper, some properties of soft radical of a soft int-ideal have been developed and soft prime int-ideal, soft semiprime int-ideal of a ring are defined. Several characterizations of soft prime (soft semiprime) int-ideals are investigated. Also it
Jayanta Ghosh +2 more
doaj +1 more source