Results 31 to 40 of about 18,030 (201)
Primordial Germ Cells: Current Knowledge and Perspectives [PDF]
Stem Cells International, 2015 Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes.
Nikolic A +4 more
openaire +5 more sources
The Journal of Poultry Science, 2012 The germ cell lineage is unique as it is the cell lineage that ensures the continuation and the variation of genetic information from one generation to the next.
James D. Glover, Michael J. McGrew
doaj +1 more source
Advanced Science, EarlyView.This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu +9 more
wiley +1 more source
Germ Cell Derivation from Pluripotent Stem Cells for Understanding In Vitro Gametogenesis
Cells, 2021 Assisted reproductive technologies (ARTs) have developed considerably in recent years; however, they cannot rectify germ cell aplasia, such as non-obstructive azoospermia (NOA) and oocyte maturation failure syndrome. In vitro gametogenesis is a promising
Tae-Kyung Hong +3 more
doaj +1 more source
Advanced Science, EarlyView.SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long +12 more
wiley +1 more source
Insights into female germ cell biology: from in vivo development to in vitro derivations
Asian Journal of Andrology, 2015 Understanding the mechanisms of human germ cell biology is important for developing infertility treatments. However, little is known about the mechanisms that regulate human gametogenesis due to the difficulties in collecting samples, especially germ ...
Dajung Jung, Kehkooi Kee
doaj +1 more source
Single-cell transcriptome landscape of ovarian cells during primordial follicle assembly in mice.
PLoS Biology, 2020 Primordial follicle assembly in the mouse occurs during perinatal ages and largely determines the ovarian reserve that will be available to support the reproductive life span.
Jun-Jie Wang +10 more
doaj +1 more source
Advanced Science, EarlyView.Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang +6 more
wiley +1 more source
Review of Differentiation and Proliferation of Primordial Germ Cells in Culture [PDF]
Journal of Fasa University of Medical Sciences, 2011 Primordial germ cells (PGCs) are highly specialized cell population that arises from the epiblast in vivo. There are three critical steps in the life cycle of these cells: 1-Specification 2-migration and proliferation 3-prenatal and postnatal sex ...
Zohreh Makoolati, Majid Naghdi
doaj +1 more source
Gonadal development in scorpion mud‐turtles, Kinosternon scorpioides, in a controlled environment
The Anatomical Record, EarlyView.Stage 20 was identified as the critical point for gonadal differentiation in Kinosternon scorpioides, providing key insights into sex determination. These findings enhance conservation strategies by supporting reproductive management and population viability in both in situ and ex situ programs. Abstract Research on gonadal development including sexual
Brenda Braga +4 more
wiley +1 more source