Results 101 to 110 of about 536,911 (259)
A Commentary on Noyce, Küssner and Sollich: Quantifying Shapes
Empirical Musicology Review, 2013 This review focuses on the statistical aspects of "Quantifying Shapes". A number of decisions made by the authors are discussed regarding the choice of methods and how exactly they are applied and their results interpreted.
Christian Hennig
doaj +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape. [PDF]
J Imaging, 2022 Farnell DJJ.
europepmc +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Multiple Centroid Methodology to analyze genotype adaptability [PDF]
Crop Breeding and Applied Biotechnology, 2009 This study was carried out to propose a modification of the centroid method. The method is modified in thechoice of the ideotype, to be defined according to the researcher's interest, using the bi-segmented regression model, ratherthan based on ...
Moysés Nascimento +4 more
doaj
Competitive and Recreational Running Kinematics Examined Using Principal Components Analysis. [PDF]
Healthcare (Basel), 2021 Quan W +5 more
europepmc +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Covariate-adjusted hybrid principal components analysis for region-referenced functional EEG data. [PDF]
Stat Interface, 2022 Scheffler AW +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source