Results 111 to 120 of about 2,259,407 (341)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PEMBUATAN PERANGKAT LUNAK PENGENALAN WAJAH MENGGUNAKAN PRINCIPAL COMPONENTS ANALYSIS

Jurnal Informatika, 2001
Face recognition is one of many important researches, and today, many applications have implemented it. Through development of techniques like Principal Components Analysis (PCA), computers can now outperform human in many face recognition tasks ...
Kartika Gunadi, Sonny Reinard Pongsitanan   +1 more
doaj  

Punching a Ticket to Cooperstown

Journal of Statistics Education, 2019
When exposed to principal components analysis for the first time, students can sometimes miss the primary purpose of the analysis. Often the focus is solely on data reduction and what to do after the dimensions of the data have been reduced is ignored ...
Philip A. Yates
doaj   +1 more source

Multilevel hybrid principal components analysis for region-referenced functional electroencephalography data. [PDF]

Stat Med, 2022
Campos E, Wolfe Scheffler A, Telesca D, Sugar C, DiStefano C, Jeste S, Levin AR, Naples A, Webb SJ, Shic F, Dawson G, Faja S, McPartland JC, Şentürk D, Autism Biomarkers Consortium for Clinical Trials.   +14 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Bayesian multivariate sparse functional principal components analysis with application to longitudinal microbiome multiomics data. [PDF]

Ann Appl Stat, 2022
Jiang L, Elrod C, Kim JJ, Swafford AD, Knight R, Thompson WK.   +5 more
europepmc   +1 more source

Using principal component analysis to develop a single-parameter screening tool for metabolic syndrome [PDF]

, 2010
Chia‐Hao Chang, Ching-Ho Yen, Mei‐Yen Chen   +2 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Application of Characteristic Model-Based Principal Component Analysis in Optimization of Flowmeter Parameters [PDF]

, 2021
Wenping Jiang, Zhencun Jiang, Lingyang Wang, Junying Min, Yi Zhu, Zhonghui Wang, Lizhuang Tang, Limin Sun   +7 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source