Results 171 to 180 of about 51,393 (297)

PrP turnover in vivo and the time to effect of prion disease therapeutics. [PDF]

PLoS Pathog
Corridon TL, O'Moore J, Seerley A, Sprague DA, Lian Y, Laversenne V, Noble B, Kamath NG, Serack FE, Shaikh AB, Erickson B, Braun C, DeSouza-Lenz K, Howard M, Chan N, Jackson WS, Reidenbach AG, Cabin DE, Vallabh SM, Grindeland Panter A, Oberbeck N, Zhao HT, Minikel EV.   +22 more
europepmc   +1 more source

Small critical RNAs in the scrapie agent

, 2009
Unconventional infectious agents cause transmissible spongiform encephalopathy (TSE) diseases including scrapie and bovine spongiform encephalopathy (BSE) in animals and Creutzfeldt-Jakob disease in humans. The protein only hypothesis claims that the TSE
Marie-Madeleine Ruchoux, Jean-Philippe Deslys, Nicolas Vignier, Pierre Lebon, Jean-Guy Fournier, Sophie Freire, Emmanuel Comoy, Steve Simoneau   +7 more
core  

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Caregiver Burden in Prion Disease. [PDF]

Dement Geriatr Cogn Dis Extra
Kovacevich A, Martin JT, Glisic K, Ogrocki P, Appleby BS.   +4 more
europepmc   +1 more source

The role of complement in synaptic degeneration

, 2012
Synapse loss is an early event of many neurodegenerative diseases including Alzheimer?s disease and Parkinson?s disease. The causes and mechanisms that underpin synapse dysfunction and degeneration are poorly understood.
Malfa, Katya
core  

Emerging directions in tauopathy research

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of
Luc Buée, Kristin R. Wildsmith, Suvarna Alladi, Taylor Bertucci, Delphine Boche, Kathryn R. Bowles, Adam Boxer, Jennifer Brummet, Sarah L. DeVos, Kristophe Diaz, Anna Jane Dreyer, Karen Duff, Claudia Duran‐Aniotz, Claire S. Durrant, Kurt Farrell, Igor C. Fontana, Nicolai Franzmeier, Bess Frost, Kanta Horie, Petr Kaňovský, Aimee W. Kao, Simin Mahinrad, Maura Malpetti, Huw R. Morris, Carla Palleis, Leonard Petrucelli, Jessica Rexach, Larisa Reyderman, Amy Rommel, James B. Rowe, Sandra M. Sanabria Bohórquez, Chihiro Sato, Michael Schöll, Anja Schneider, Rohan de Silva, Heather M. Snyder, Lawren VandeVrede, Andrew W. Varga, Jacob W. Vogel, Felix L. Yeh, Andrew S. Yoo, Maria C. Carrillo   +41 more
wiley   +1 more source

A critical perspective of prion disease surveillance in Brazil. [PDF]

Front Neurosci
Barbosa BJAP, Montenegro MLV, da Cunha JEG.   +2 more
europepmc   +1 more source

Brain regional susceptibility to tauopathy in individuals at risk for chronic traumatic encephalopathy

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Chronic traumatic encephalopathy (CTE) is a tauopathy linked to repetitive head impacts. Factors influencing brain regional susceptibility to tau deposition and spreading remain unclear. METHODS We used three datasets: [18F]flortaucipir positron emission tomography (PET) in 157 former professional American football players and 53 ...
Tim L. T. Wiegand, Anna Rubinski, Leonard B. Jung, Nicolai Franzmeier, Hector Arciniega, Parsa Ravanfar, Anna Dewenter, Michael L. Alosco, Yorghos Tripodis, Yi Su, Hillary Protas, Alexander P. Lin, Ofer Pasternak, Kewei Chen, Michael J. Coleman, Sylvain Bouix, Charles H. Adler, Laura J. Balcer, Charles Bernick, Jeffrey L. Cummings, Robert A. Stern, Eric M. Reiman, Martha E. Shenton, Michael Ewers, Inga K. Koerte, for the DIAGNOSE CTE Research Project   +25 more
wiley   +1 more source

Human Prion Disease: Pathogenesis, Diagnosis and Public Health. [PDF]

Viruses
Bellini P, Ruggiero F, Benedetti A, Cereda CW, Gobbi C, Bianco G, Bongiovanni M.   +6 more
europepmc   +1 more source

Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena   +10 more
wiley   +1 more source