Results 191 to 200 of about 51,393 (297)

Refined Transgenic Mouse Models Which Recapitulate the Natural Features of Chronic Wasting Disease With Rapid Prion Disease Onsets. [PDF]

J Infect Dis
DeFranco JP, Kim S, Atkinson ZN, Crowell J, Lei S, Bian J, Telling GC.   +6 more
europepmc   +1 more source

Upregulated PKM2 Protects Dopaminergic Neurons From Oxidative Damage Through Nrf2 Transactivation in an MPTP‐Induced Mouse Model of Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Oxidative stress induced by MPTP promotes hnRNP A1/A2–dependent alternative splicing toward PKM2 in dopaminergic neurons. Elevated PKM2 transactivates Nrf2, enhances antioxidant gene expression, and protects neurons from oxidative damage and degeneration.
Meng Mei, Qian‐qian Miao, Meng‐ke Li, Hao‐ran Wang, Jian‐hua Ding, Gang Hu, Yao Wei   +6 more
wiley   +1 more source

A Drosophila model of prion disease and its metabolic changes in the brain. [PDF]

Animal Model Exp Med
Wang D, Sun Z, Wen P, Zhao M, He Y, Gou F, Wang J, Fan Q, Li X, Ma T, Wang X, Li W, Chen S, Zhao D, Yang L.   +14 more
europepmc   +1 more source

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Knockout of P2Y12 receptor facilitates neuronal envelopment by reactive microglia and accelerates prion disease. [PDF]

J Neuroinflammation
Makarava N, Safadi T, Bocharova O, Mychko O, Pandit NP, Molesworth K, Eyo UB, Baskakov IV.   +7 more
europepmc   +1 more source

'Prion' Diseases

Journal of the Royal College of Physicians of London, 1994
openaire   +2 more sources

Networks of Indirect Contact Promote Spread of an Environmentally Transmitted Pathogen in a Highly Social Species

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using behavioral observations and network simulations, we evaluate direct and indirect transmission of the MTBC pathogen M. mungi in banded mongooses. Incorporating intergroup scent marking reveals that environmentally mediated, socially directed pathways can promote spread at low transmissibility, elevating population prevalence even when direct ...
Jack R. Leitch, Neil R. Jordan, John M. Drake, Michael A. Cant, Kathleen A. Alexander   +4 more
wiley   +1 more source

Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease. [PDF]

Sci Adv
Yan R, Zhang Y, Zhang J, Zhang X, Han Y, Wang M, Wang D, Huang S, Liu W, Shi Q, Dong X, Zou WQ, Li Z, Ma J.   +13 more
europepmc   +1 more source

Dysregulated microRNAs in blood correlate with central nervous system neuropathology of prion disease. [PDF]

Vet Res
Pérez-Lázaro S, Martín-Burriel I, Cozzuto L, Ponomarenko J, Badiola JJ, Bolea R, Toivonen JM.   +6 more
europepmc   +1 more source

Creutzfeldt‐Jakob‐Like Presentation in Anti‐AMPAR Encephalitis

Annals of Neurology, Volume 99, Issue 6, Page 1466-1467, June 2026.
Kate Durbano, Marie Belley, Delphine Leclercq, Louis Cousyn   +3 more
wiley   +1 more source