Results 191 to 200 of about 10,379,704 (316)

Quantifying prion disease penetrance using large population control cohorts

Science Translational Medicine, 2016
E. Minikel, E. Minikel, S. M. Vallabh, S. M. Vallabh, M. Lek, M. Lek, K. Estrada, K. Estrada, K. Samocha, K. Samocha, J. Sathirapongsasuti, Cory Y. McLean, J. Tung, L. P. Yu, P. Gambetti, Janis E. Blevins, Shulin Zhang, Yvonne Cohen, Wei F. Chen, Masahito Yamada, T. Hamaguchi, N. Sanjo, Hidehiro Mizusawa, Yosikazu Nakamura, T. Kitamoto, S. Collins, A. Boyd, R. Will, R. Knight, Claudia Ponto, I. Zerr, Theo F. J. Kraus, S. Eigenbrod, A. Giese, M. Calero, J. Pedro-Cuesta, S. Haïk, J. Laplanche, E. Bouaziz-Amar, J. Brandel, S. Capellari, Piero Parchi, A. Poleggi, A. Ladogana, A. O’Donnell-Luria, A. O’Donnell-Luria, K. Karczewski, K. Karczewski, Jamie L. Marshall, Jamie L. Marshall, M. Boehnke, M. Laakso, K. Mohlke, A. Kähler, K. Chambert, S. Mccarroll, Patrick F. Sullivan, Patrick F. Sullivan, C. Hultman, S. Purcell, P. Sklar, S. Lee, A. Rozemuller, C. Jansen, A. Hofman, R. Kraaij, J. Rooij, M. A. Ikram, A. Uitterlinden, C. Duijn, Mark J. Daly, M. J. Daly, D. MacArthur, D. MacArthur   +73 more
semanticscholar   +1 more source

Genome‐Wide Association Study of Leukocyte Traits Reveals Candidate Genes Associated With Immunity in Holstein Cattle From Southern China

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
A genome‐wide association study (GWAS) was conducted to analyse variations in white blood cell (WBC) counts and composition traits among 200 Holstein cows in Southern China. The results identified two candidate genes, BEND5 and FOXJ3, associated with WBC count, lymphocyte percentage and basophil percentage.
Chenhui Liu, Jie Yu, Zhuxia Zhong, Xiuzhong Hu, Min Xiang, Xiaoyong Du, Mohammad Abdul Latif, Wenxuan Wang, Liangyu Shi, Hongbo Chen, Lei Cheng   +10 more
wiley   +1 more source

Insights from Therapeutic Studies for PrP Prion Disease.

Cold Spring Harbor Perspectives in Medicine, 2017
Kenta Teruya, K. Doh-ura
semanticscholar   +1 more source

Strain Traits of Intracranially Administered L‐Type Bovine Spongiform Encephalopathy Prions Are not Significantly Modified During Intraspecies Transmission in Cynomolgus Monkeys

Microbiology and Immunology, Volume 70, Issue 3, Page 166-174, March 2026.
ABSTRACT Among the three prion strains of bovine spongiform encephalopathy (BSE), classical BSE (C‐BSE) prions are known causative agents of variant Creutzfeldt–Jakob disease. By contrast, human infections with L‐type (L‐) or H‐type (H‐) BSE prions have not been reported.
Ken'ichi Hagiwara, Hiroaki Shibata, Minoru Tobiume, Yuko Sato, Keiko Ohto, Sachi Okabayashi, Nozomi Nakano, Motohiro Horiuchi, Fumiko Ono   +8 more
wiley   +1 more source

Using the marine flyways concept to accelerate ocean conservation

Journal of Applied Ecology, Volume 63, Issue 3, March 2026.
Implementing the marine flyways framework can secure ecological connectivity across the marine environment, including in synergistic implementation of existing regional policy instruments and multiple multilateral environmental agreements, including CMS, the Kunming‐Montreal Global Biodiversity Framework (KMGBF) and the Agreement on the Conservation ...
Joanne M. Morten, Aline Küehl‐Stenzel, G. Barry Baker, Graeme A. Taylor, Virginia A. Garcia Alonso, Victoria R. Jones, Nicola Crockford, Tammy E. Davies   +7 more
wiley   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

Caregiver Burden in Prion Disease. [PDF]

Dement Geriatr Cogn Dis Extra
Kovacevich A, Martin JT, Glisic K, Ogrocki P, Appleby BS.   +4 more
europepmc   +1 more source

Mobile Powerhouses: Mitochondria Transfer via Tunnelling Nanotubes in Brain Health and Neurodegenerative Diseases

European Journal of Neuroscience, Volume 63, Issue 6, March 2026.
Within the brain microenvironment, mitochondria are preferentially transferred from glial cells to metabolically stressed neurons via tunnelling nanotubes (TNTs). This intercellular exchange restores bioenergetic homeostasis and contributes to mitochondrial quality control through transmitophagy.
Anna Henrich, Hannah Scheiblich
wiley   +1 more source

A critical perspective of prion disease surveillance in Brazil. [PDF]

Front Neurosci
Barbosa BJAP, Montenegro MLV, da Cunha JEG.   +2 more
europepmc   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, Volume 293, Issue 5, Page 1495-1515, March 2026.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source