Results 61 to 70 of about 4,898,785 (204)

Treatment of Prion Disease with Heterologous Prion Proteins. [PDF]

PLoS ONE, 2015
Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep are fatal neurodegenerative diseases for which there is no effective treatment.
Pamela J Skinner, Hyeon O Kim, Damani Bryant, Nikilyn J Kinzel, Cavan Reilly, Suzette A Priola, Anne E Ward, Patricia A Goodman, Katherine Olson, Davis M Seelig   +9 more
doaj   +1 more source

PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer [PDF]

, 2002
Up to 15% of free-ranging mule deer in northeastern Colorado and southeastern Wyoming, USA, are afflicted with a prion disease, or transmissible spongiform encephalopathy (TSE), known as chronic wasting disease (CWD).
Keulen, L.J.M., van, van Keulen, L.J.M., Miller, M.W., Oesch, B., Hoover, E.A., Langeveld, J.P.M., Sigurdson, C.J., Barillas-Mury, C.   +7 more
core   +1 more source

Imaging of prion diseases [PDF]

Journal of Magnetic Resonance Imaging, 2012
AbstractPrion diseases are caused by self‐replicating proteins that induce lethal neurodegenerative disorders. In the last decade, the understanding of the different clinical, pathological, and neuroimaging phenotypes of this group of disorders has evolved paralleling the advances in prion molecular biology.
Laurent, Letourneau-Guillon, Ryan, Wada, Walter, Kucharczyk   +2 more
openaire   +2 more sources

Genetic variability of the prion protein gene (PRNP) in wild ruminants from Italy and Scotland [PDF]

, 2009
The genetics of the prion protein gene (PRNP) play a crucial role in determining the relative susceptibility to transmissible spongiform encephalopathies (TSEs) in several mammalian species.
Acutis, Pier Luigi, Pier Luigi Acutis, Ezio Ferroglio, Simone Peletto, Hugh W. Reid, Perucchini, Matteo, Serena Robetto, Acin, Cristina, Bozzetta, Elena, Reid, Hugh W., Dalgleish, Mark P., Orusa, Riccardo, Elena Bozzetta, Ferroglio, Ezio, Sacchi, Paola, Paula Stewart, Daniela Meloni, Wilfred Goldmann, Meloni, Daniela, Gennero, Silvia, Riccardo Orusa, Roberto Rasero, Rasero, Roberto, Cristina Acín, Matteo Perucchini, Mark P. Dalgleish, Goldmann, Wilfred, Stewart, Paula, Maria Caramelli, Silvia Gennero, Caramelli, Maria, Robetto, Serena, Peletto, Simone, Paola Sacchi   +33 more
core   +1 more source

Persistence of viral RNA in North American elk experimentally infected with an ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Scientific Reports
White-tailed deer (Odocoileus virginianus) have emerged as a reservoir host for SARS-CoV-2 given their susceptibility to infection and demonstrated high rates of seroprevalence and infection across the United States.
Paola M. Boggiatto, Alexandra Buckley, Eric D. Cassmann, Hannah Seger, Steven C. Olsen, Mitchell V. Palmer   +5 more
doaj   +1 more source

Visualization of avian influenza virus infected cells using self-assembling fragments of green fluorescent protein

Electronic Journal of Biotechnology, 2016
Background: Avian influenza viruses (AIVs) are influenza A viruses which are isolated from domestic and wild birds. AIVs that include highly pathogenic avian influenza viruses (HPAIVs) are a major concern to the poultry industry because they cause ...
Katsushi Kanehira, Yuko Uchida, Takehiko Saito   +2 more
doaj   +1 more source

Sources and sinks of influenza A virus genomic diversity in swine from 2009 to 2022 in the United States

Journal of Virology
Influenza A virus (IAV) in swine in the U.S. is surveilled to monitor genetic evolution to inform intervention efforts and aid pandemic preparedness. We describe data from the U.S.
Garrett M. Janzen, Blake T. Inderski, Jennifer Chang, Zebulun W. Arendsee, Alicia Janas-Martindale, Mia Kim Torchetti, Amy L. Baker, Tavis K. Anderson   +7 more
doaj   +1 more source

Oxidative Damage to Nucleic Acids in Human Prion Disease

Neurobiology of Disease, 2002
Recently, several studies proposed a physiological role for the cellular prion protein (PrPc) in defense against oxidative stress. Since the pathogenesis of prion disease necessarily involves a disturbance of PrPc homeostasis, we hypothesized that such ...
Marin Guentchev, Sandra L. Siedlak, Christa Jarius, Fabrizio Tagliavini, Rudy J. Castellani, George Perry, Mark A. Smith, Herbert Budka   +7 more
doaj   +1 more source

Prion disease

Rinsho Shinkeigaku, 2010
Human prion diseases are classified into 3 categories according to etiologies: idiopathic of unknown cause, acquired of infectious origin, and genetic by PRNP mutation. The surveillance committee have analyzed 2,494 cases and identified 1,402 as prion diseases.
openaire   +4 more sources

The presence of valine at residue 129 in human prion protein accelerates amyloid formation [PDF]

, 2005
The polymorphism at residue 129 of the human PRNP gene modulates disease susceptibility and the clinicopathological phenotypes in human transmissible spongiform encephalopathies.
Tahiri-Alaoui, Abdessamad, Gill, A, Shaw, Michael, Shaw, M, Baskakov, I, Breydo, L, James, W, Tahiri-Alaoui, A, Disterer, Petra, Gill, Andrew, Baskakov, Ilia, Breydo, Leonid, Disterer, P, James, William   +13 more
core   +1 more source