Results 81 to 90 of about 42,402 (225)
Frontiers in Neuroscience, 2015 Organotypic cerebellar slices represent a suitable model for characterizing and manipulating prion replication in complex cell environments. Organotypic slices recapitulate prion pathology and are amenable to drug testing in the absence of a blood-brain ...
Hanna eWolf +7 more
doaj +1 more source
[Is Parkinson's disease a prion disease?].
Revue neurologique, 2015 The accumulation of a specific protein in aggregated form is a common phenomenon in human neurodegenerative diseases. In Parkinson's disease, this protein is α-synuclein which is a neuronal protein of 143 amino acids. With a monomeric conformation in solution, it also has a natural capacity to aggregate into amyloid structures (dimers, oligomers ...
Brandel, Jean-Philippe +3 more
openaire +3 more sources
Movement Disorders, EarlyView.Abstract Background The identification of Parkinson's disease (PD) subtypes is crucial for predicting the disease course and designing personalized therapeutic strategies. Objectives The aim of the study was to characterize the heterogeneity of the spatiotemporal evolutionary patterns of striatal dopamine depletion and cerebral hypoperfusion in PD ...
Yeeun Sun +9 more
wiley +1 more source
Neuroprotection, EarlyView.Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji +6 more
wiley +1 more source
Reverse zoonosis of the 2022–2023 human seasonal H3N2 detected in swine
npj VirusesThe Iowa State University Veterinary Diagnostic Laboratory detected nineteen human-to-swine reverse zoonoses of the 2022–2023 human seasonal H3N2 between November 2022 and November 2023. Cases from seven U.S.
Michael A. Zeller +6 more
doaj +1 more source
Effects of Pseudorabies Virus Infection on the Tracheobronchial Lymph Node Transcriptome
Bioinformatics and Biology Insights, 2015 This study represents the first swine transcriptome hive plots created from gene set enrichment analysis (GSEA) data and provides a novel insight into the global transcriptome changes occurring in tracheobronchial lymph nodes (TBLN) and spanning the ...
Laura C. Miller +3 more
doaj +1 more source
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
Precision Medical Sciences, EarlyView.This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source
Wildlife Letters, EarlyView.We examined changes in perceived risks associated with chronic wasting disease (CWD) and perceived trust in wildlife agencies over time across 10 studies in eight states. Results indicated that perceived risks to both deer and humans declined the longer the disease had been in a state. Results also indicated that agency trust evaluations were positive,
Jerry J. Vaske, Craig A. Miller
wiley +1 more source
Wild pigs (Sus scrofa) prefer inoculated peanuts over whole‐kernel corn in cafeteria‐style study
Wildlife Society Bulletin, EarlyView.In this study, we explored bait preference of wild pigs (Sus scrofa), a highly invasive species where primary removal efforts include the use of bait and corral‐style trapping. In addition, we investigated preferences of a common nontarget to identify a bait that is preferred by wild pigs and not by white‐tailed deer (Odocoileus virginianus).
Justine L. Smith +5 more
wiley +1 more source