Results 151 to 160 of about 78,455 (315)

SKALE: An Interpretable Multiscale Machine Learning Model for Decoding Phase‐Specific Protein Aggregation in Neurodegenerative Proteinopathies

Aggregate, Volume 7, Issue 2, February 2026.
Protein aggregation drives diverse degenerative diseases, yet its molecular origins are difficult to predict. SKALE uses interpretable machine learning to link sequence, structure, and dynamics, revealing how local structural weakening triggers aggregation.
Wei Xuan Wilson Loo, Jia Shen Sio, Keyin Yap, Yan Shan Loo, Hui Xuan Lim, Shuangyue Zhang, Huitao Liu, Chen Seng Ng   +7 more
wiley   +1 more source

A Phase 1 Study of the Pharmacokinetics, Safety, and Tolerability of Posdinemab (JNJ‐63733657) in Healthy Chinese Adults

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Posdinemab, a humanized immunoglobulin G1/κ monoclonal antibody, binds with high affinity to phosphorylated tau protein which is associated with Alzheimer's disease (AD) pathophysiology. Posdinemab reduced tau seeding in murine models and was well tolerated in Phase‐1 clinical studies.
Fangfang Wang, Juanfang Liu, Daisy Bai, Lingjue Li, Maggie Fedgchin, David Henley, Haiyan Li, Fan Zhang   +7 more
wiley   +1 more source

Prions and prion diseases [PDF]

The FEBS Journal, 2007
openaire   +2 more sources

Heat shock protein 10 as a chaperone modulating α‐synuclein amyloid fibril formation

Protein Science, Volume 35, Issue 2, February 2026.
Abstract HSP10 is a well‐known human co‐chaperone that interacts with HSP60 to comprise the HSP60/10 chaperonin complex which upholds mitochondrial proteostasis. HSP10 also demonstrates independent roles in binding to misfolded proteins and interacts with several amyloidogenic client proteins.
Johan N. K. Larsson, Ranjeet Kumar, Fiamma Ayelen Buratti, Sofie Nyström, Pernilla Wittung‐Stafshede, Per Hammarström   +5 more
wiley   +1 more source

Notch-1 activation and dendritic atrophy in prion disease

, 2005
Nako Ishikura, Jared L. Clever, Essia Bouzamondo-Bernstein, Erik Samayoa, Stanley B. Prusiner, Eric J. Huang, Stephen J. DeArmond   +6 more
openalex   +1 more source

Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains [PDF]

, 2015
Camilo Duque Velásquez, Chiye Kim, Allen Herbst, Nathalie Daude, María Carmen Garza, Holger Wille, Judd M. Aiken, Debbie McKenzie   +7 more
openalex   +1 more source

Changing the Flow: How EUS‐Guided Drainage is Reshaping the Management of Distal Malignant Biliary Obstruction

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Endoscopic ultrasound‐guided biliary drainage (EUS‐BD) has evolved from a rescue therapy into a viable alternative to endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous drainage for distal malignant biliary obstruction (dMBO).
Jeska A. Fritzsche, Inge de Vries, Jeanin E. van Hooft, Rogier P. Voermans, Roy L. J. van Wanrooij   +4 more
wiley   +1 more source

Functional Genomics Approach for Identification of Molecular Processes Underlying Neurodegenerative Disorders in Prion Diseases

, 2012
Urmila Basu, Le Luo Guan, S. S. Moore
openalex   +2 more sources

Region-specific glial homeostatic signature in prion diseases is replaced by a uniform neuroinflammation signature, common for brain regions and prion strains with different cell tropism

, 2020
Natallia Makarava, Jennifer C. Chang, Kara Molesworth, Ilia V. Baskakov   +3 more
openalex   +1 more source

Occupational balance, quality of life, occupational performance, and disease‐related factors in people with multiple sclerosis: A case–control study

Australian Occupational Therapy Journal, Volume 73, Issue 1, February 2026.
Abstract Importance Multiple sclerosis is a chronic neurological progressive disease that can lead to different impairments. It may also impact individuals' quality of life and daily living, including occupational performance and occupational balance. However, occupational balance has not been thoroughly described in this population.
Araceli Ortiz‐Rubio, Eva Månsson Lexell, Carita Håkansson, Alba Navas‐Otero   +3 more
wiley   +1 more source