Results 181 to 190 of about 78,455 (315)

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Samuel Peña‐Díaz, Yanting Jiang, Zhefei Zhang, Anders Daugberg, Pedro Ferreira, Marcos López Hernández, Chandrika Mittal, Maria Joao Ramos, Jan Skov Pedersen, Morten Kam Dahl Dueholm, Cao Qin, Huabing Wang, Daniel E. Otzen   +12 more
wiley   +1 more source

Geographic Diversity in the Incidence of Human Prion Diseases - China, 2006-2019. [PDF]

China CDC Wkly, 2023
Shi Q, Xiao K, Gao L, Wu Y, Zhou W, Liang D, Chen C, Dong X.   +7 more
europepmc   +1 more source

Creutzfeldt-Jakob Disease Patients with Congophilic Kuru Plaques Have the Missense Variant Prion Protein Common to Gerstmann-Straussler Syndrome

, 1991
克美 堂浦, Katsumi Doura, カツミ ドウウラ   +2 more
openalex   +2 more sources

Brain‐peripheral proteome crosstalk in Alzheimer's disease with and without diabetes mellitus

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract BACKGROUND Although considerable research has investigated diabetes mellitus (DM) as a risk factor for Alzheimer's disease (AD) dementia, the mechanistic understanding of the associations between peripheral and central biological processes in AD and AD within DM remains limited.
Anat Yaskolka Meir, Xingyan Wang, Shinya Tasaki, Vishal Sarsani, Aron S. Buchman, Steven E. Arnold, David A. Bennett, Vladislav A. Petyuk, Liming Liang, Ana W. Capuano, Zoe Arvanitakis   +10 more
wiley   +1 more source

Etiology matters: genetic and acquired prion diseases engage different mechanisms at a presymptomatic stage. [PDF]

Neural Regen Res, 2023
Jackson WS.
europepmc   +1 more source

Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease [PDF]

, 2014
Nicole T. Watt, Heledd Jarosz-Griffiths, Nigel M. Hooper   +2 more
openalex   +1 more source

TDP‐43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP‐43 Aggregation in Neurodegenerative Diseases?

BioEssays, Volume 48, Issue 1, January 2026.
TDP‐43 hyperphosphorylation occurs in neurodegenerative diseases, however, it is not a driver of TDP‐43 aggregation, but enhances TDP‐43 solubility, suggesting that TDP‐43 hyperphosphorylation is protective. Toxicity may arise from a broader phosphorylation‐driven cellular pathway disruption.
Simone Mosna, Dorothee Dormann
wiley   +1 more source

Early Diagnostic Measures to Confirm the Diagnosis of Human Prion Diseases. [PDF]

Cureus, 2023
Desai N, Purzycki T.
europepmc   +1 more source

The Interface of Oral and Brain Health: Current Insights Into the Bidirectional Relationship Between Alzheimer's Disease and Periodontitis

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Bidirectional Pathogenesis Between AD and Periodontitis. Periodontal pathogens reach the brain via hematogenous/trigeminal/oral–intestinal pathways, triggering neuroinflammation and Aβ plaques to drive AD. Conversely, AD disrupts bone homeostasis (via Aβ, endocrine/autonomic dysregulation) to aggravate periodontitis.
Weidong Zhang, Shasha Li, Yajun Cui, Yuhui Lun, Hongrui Liu, Minqi Li   +5 more
wiley   +1 more source

Therapeutic window for treatment of prion disease defined by timed depletion of Prion protein [PDF]

Barry Bradford, Alison Marshall, Nadia L. Tuzi, Dorothy Kisielewski, Kim Summers, V. Hugh Perry, Pedro Piccardo, Alan R. Clarke, Jean Manson, Jean C. Manson   +9 more
openalex   +1 more source