Results 131 to 140 of about 50,704 (271)

Brain‐peripheral proteome crosstalk in Alzheimer's disease with and without diabetes mellitus

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract BACKGROUND Although considerable research has investigated diabetes mellitus (DM) as a risk factor for Alzheimer's disease (AD) dementia, the mechanistic understanding of the associations between peripheral and central biological processes in AD and AD within DM remains limited.
Anat Yaskolka Meir, Xingyan Wang, Shinya Tasaki, Vishal Sarsani, Aron S. Buchman, Steven E. Arnold, David A. Bennett, Vladislav A. Petyuk, Liming Liang, Ana W. Capuano, Zoe Arvanitakis   +10 more
wiley   +1 more source

Convergent generation of atypical prions in knockin mouse models of genetic prion disease

The Journal of Clinical Investigation
Most cases of human prion disease arise due to spontaneous misfolding of WT or mutant prion protein, yet recapitulating this event in animal models has proven challenging. It remains unclear whether spontaneous prion generation can occur within the mouse
Surabhi Mehra, Matthew E.C. Bourkas, Lech Kaczmarczyk, Erica Stuart, Hamza Arshad, Jennifer K. Griffin, Kathy L. Frost, Daniel J. Walsh, Surachai Supattapone, Stephanie A. Booth, Walker S. Jackson, Joel C. Watts   +11 more
doaj   +1 more source

TDP‐43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP‐43 Aggregation in Neurodegenerative Diseases?

BioEssays, Volume 48, Issue 1, January 2026.
TDP‐43 hyperphosphorylation occurs in neurodegenerative diseases, however, it is not a driver of TDP‐43 aggregation, but enhances TDP‐43 solubility, suggesting that TDP‐43 hyperphosphorylation is protective. Toxicity may arise from a broader phosphorylation‐driven cellular pathway disruption.
Simone Mosna, Dorothee Dormann
wiley   +1 more source

Correction: Corrigendum: Rescue of neurophysiological phenotype seen in PRP null mice by transgene encoding human prion protein [PDF]

, 1995
Whittington, Miles A, Sidle, Katie CL, Gowland, Ian, Meads, Julie, Hill, Andrew F, Palmer, M, Jefferys, John GR, Collinge, John   +7 more
openalex   +1 more source

The Interface of Oral and Brain Health: Current Insights Into the Bidirectional Relationship Between Alzheimer's Disease and Periodontitis

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Bidirectional Pathogenesis Between AD and Periodontitis. Periodontal pathogens reach the brain via hematogenous/trigeminal/oral–intestinal pathways, triggering neuroinflammation and Aβ plaques to drive AD. Conversely, AD disrupts bone homeostasis (via Aβ, endocrine/autonomic dysregulation) to aggravate periodontitis.
Weidong Zhang, Shasha Li, Yajun Cui, Yuhui Lun, Hongrui Liu, Minqi Li   +5 more
wiley   +1 more source

Analysis of differences in prion protein gene (PRNP) polymorphisms between Algerian and Southern Italy's goats [PDF]

, 2018
Khaled Fantazi, Sergio Migliore, Samia Kdidi, Luca Racinaro, Hakim Tefiel, Rachid Boukhari, Giovanni Federico, Vincenzo Di Marco Lo Presti, Semir Bechir Suheil Gaouar, María Vitale   +9 more
openalex   +1 more source

Peripheral Signatures of Multidimensional Pathology in Symptomatic and Asymptomatic Creutzfeldt–Jakob Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Plasma biomarkers in CJD reveal multisystem involvement, with neuronal injury markers showing strong discriminative performance and vascular proteins indicating blood–brain barrier dysfunction. In asymptomatic PRNP mutation carriers, biomarker changes are minimal and emerge mainly near disease onset ABSTRACT Background Plasma markers of neuronal injury
Zhong‐Yun Chen, Min Chu, Yi‐Hao Wang, Rui Liu, Jing Zhang, Ai‐ling Yue, Hua Lu, Qian‐qian He, Jia‐hui Hou, Yu‐fei Chen, Hong Ye, Li‐Yong Wu   +11 more
wiley   +1 more source

Prion soft amyloid core driven self-assembly of globular proteins into bioactive nanofibrils

, 2019
Weiqiang Wang, Susanna Navarro, Rafayel A. Azizyan, Manuel Bañó‐Polo, Sebastián Esperante, Andrey V. Kajava, Salvador Ventura   +6 more
openalex   +2 more sources

Prion and Prion-like Proteins

YAKUGAKU ZASSHI, 2019
Kazunori Sano, Masato Hosokawa
openaire   +2 more sources

Oligodendroglial Densities and Myelin Structure Are Altered in TDP‐43 Related Amyotrophic Lateral Sclerosis

Glia, Volume 74, Issue 1, January 2026.
TDP‐43Q331K mice exhibit altered proliferative dynamics in oligodendrocytes and their precursors. Oligodendroglial cell death is evident in TDP‐43Q331K mice. TDP‐43Q331K mice display altered myelin reflectance and pathology in the spinal cord. ABSTRACT Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the ...
Katherine N. Lewis, Georgina A. Craig, Joel Mason, Doris Tomas, Brittany Cuic, Adam K. Walker, David G. Gonsalvez, Bradley J. Turner, Samantha K. Barton   +8 more
wiley   +1 more source