Results 151 to 160 of about 3,400,014 (272)
The Exceptions to the Central Dogma of Biology—Bending the Rules and Extending the Scope
Natural Sciences, Volume 6, Issue 4, October 2026.ABSTRACT The central dogma is an organizing framework for how information flows in biological systems. First presented in 1957 by Francis Crick in his talk “On Protein Synthesis” as a fundamental hypothesis of how information is transferred from DNA to proteins but not out of proteins, it is now introduced in cell biology textbooks as three sequential ...
Anat Ben‐Zvi
wiley +1 more source
, 2009 The physicochemical nature of the infectious agent in prion diseases creates asignificant challenge for decontamination services. It has been shown to be both resistant tostandard methods of decontamination, used to inactivate viruses and bacteria, and ...
Howlin, Robert
core +1 more source
Modular Metalloprotein Nanowires With Semiconductor‐Scale Conductivity and Tunable Redox Behavior
Small Structures, Volume 7, Issue 10, October 2026.Conductive protein nanowires are built by aligning three different metalloproteins along an ultrastable filament scaffold. The resulting micrometer‐length nanowires reach conductivities of 1.75 S cm−1. Redox behavior is set by the metalloprotein chosen, while conductivity is governed by the spacing the scaffold imposes, making both independently ...
Nga T. Lam +3 more
wiley +1 more source
Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.This study investigates the role of manganese metabolism in Alzheimer's disease (AD) pathogenesis. Using integrated bioinformatics and machine learning, four core manganese‐related diagnostic genes (TSPO, PTBP1, GLO1, ACACB) were identified, showing high diagnostic accuracy. The analysis also revealed significant immune microenvironment alterations and
Shengnan Shu +3 more
wiley +1 more source
Die Rolle von PrPC in der neuronalen Differenzierung und die Ausbreitung der infektiösen Isoform PrPSc durch Mikrovesikel [PDF]
, 2008 Prion diseases or transmissible spongiform encephalopathies (TSEs) are rare neurological disorders that may be of genetic or infectious origin, but most frequently occur sporadically in humans. Their outcome is invariably fatal.
Barenco Montrasio, Maria Grazia
core
De Novo Autogenic Engineered Living Functional Materials
Advanced Materials, Volume 38, Issue 52, 16 September 2026.A versatile platform for de novo autogenic engineered living materials is presented, leveraging protein mining, computational modeling, and synthetic biology. By reprogramming the Escherichia coli curli machinery with β‐solenoid proteins from non‐model bacteria, macroscopic biomaterials with enhanced mechanical properties, UV‐C irradiation protection ...
Hoda M. Hammad +9 more
wiley +1 more source
Molecular mechanism of neuritogenesis driven by prion protein [PDF]
, 2018 The cellular form of prion protein (PrPC) is a ubiquitous component of both the central and peripheral nervous systems from early stages of development to adulthood.
Nguyen, Thi Anh Xuan
core
Advanced Science, Volume 13, Issue 50, 7 September 2026.This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu +6 more
wiley +1 more source
Convergent generation of atypical prions in knockin mouse models of genetic prion disease
The Journal of Clinical InvestigationMost cases of human prion disease arise due to spontaneous misfolding of WT or mutant prion protein, yet recapitulating this event in animal models has proven challenging. It remains unclear whether spontaneous prion generation can occur within the mouse
Surabhi Mehra +11 more
doaj +1 more source