Results 161 to 170 of about 97,377 (307)

Correction: Corrigendum: Rescue of neurophysiological phenotype seen in PRP null mice by transgene encoding human prion protein [PDF]

, 1995
Whittington, Miles A, Sidle, Katie CL, Gowland, Ian, Meads, Julie, Hill, Andrew F, Palmer, M, Jefferys, John GR, Collinge, John   +7 more
openalex   +1 more source

Single‐nucleus RNA sequencing reveals ferroptosis as a potential contributor to the pathogenesis of focal cortical dysplasia

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
1. A single‐cell analysis was conducted to investigate the transcriptomic changes in cells within focal cortical dysplasia (FCD). 2. Ferroptosis may play a significant role in the pathogenesis of FCD, potentially contributing to cellular damage and epileptogenesis. 3.
Qingyang Zeng, Fengjun Zhu, Dezhi Cao, Yang Sun, Lin Li, Zeshi Tan, Cong Li, Xiaofan Ren, Yidi Liu, Zhiqiang Lin, Dongfang Zou   +10 more
wiley   +1 more source

When Viruses Talk through Extracellular Vesicles: a New Perspective on Sars‐Cov‐2‐Induced Neurodegeneration

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT SARS‐CoV‐2 infection is linked to persistent neurological symptoms Post‐Acute Sequelae SARS‐CoV‐2 (neuro‐PASC) and elevated risk of neurodegenerative disease, but molecular events connecting acute viral injury to long‐term CNS dysfunction remain unclear.
Gunjan Bawne, Loet Coenen, Erik Nutma, Jinte Middeldorp, Magdalena J. Lorenowicz   +4 more
wiley   +1 more source

An ALS‐associated mutation in the C‐terminal α‐helix of TDP‐43 uncouples condensate formation and amyloid assembly

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP‐43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, including fibrils composed
Emily J. Byrd, Joel A. Crossley, Chalmers C. C. Chau, Paolo Actis, Antonio N. Calabrese   +4 more
wiley   +1 more source

Identification of an altered gut microbiome and the protective effect of microbiome changer in prion diseases

Veterinary Research
Prion diseases are fatal and contagious brain disorders caused by a pathogenic prion protein (PrPSc) derived from the benign prion protein (PrPC). To date, there are no therapeutic substances to completely block prion diseases. Thus, the development of a
Yong-Chan Kim, Sae-Young Won, Byung-Hoon Jeong   +2 more
doaj   +1 more source

A composition‐matching algorithm, MatchIDR, identifies prion‐like domains that localize to stress granules

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Intrinsically disordered regions (IDRs) play important molecular roles in cells even though they do not adopt a stable structure. Relative to structured regions, IDRs have skewed amino acid compositions favoring polar and charged amino acids. This feature is a major contributor to the biophysical behavior and in vivo activity of IDRs, but the ...
Sean M. Cascarina, Kacy R. Paul, Larissa L. Ford, Eric D. Ross   +3 more
wiley   +1 more source

A bipolar functionality of Q/N‐rich proteins: Lsm4 amyloid causes clearance of yeast prions [PDF]

, 2013
Keita Oishi, Hiroshi Kurahashi, Chan‐Gi Pack, Yasushi Sako, Yoshikazu Nakamura   +4 more
openalex   +1 more source

A Review of Metal–Organic Framework (MOF) Based Active Food Packaging: Materials Selection, Cellulose Matrices Current Advances, Synthesis and Characterizations

Packaging Technology and Science, Volume 39, Issue 5, Page 533-572, May 2026.
Active packaging offers an effective approach to extending food shelf life. This review summarizes the past decade of progress in metal‐organic framework (MOF)‐based active food packaging, highlighting material selection, characterization, challenges, and future prospects.
Belladini Lovely, Young‐Teck Kim, Haibo Huang, Novitri Hastuti, Su Jung Hong   +4 more
wiley   +1 more source

Convergent generation of atypical prions in knockin mouse models of genetic prion disease

The Journal of Clinical Investigation
Most cases of human prion disease arise due to spontaneous misfolding of WT or mutant prion protein, yet recapitulating this event in animal models has proven challenging. It remains unclear whether spontaneous prion generation can occur within the mouse
Surabhi Mehra, Matthew E.C. Bourkas, Lech Kaczmarczyk, Erica Stuart, Hamza Arshad, Jennifer K. Griffin, Kathy L. Frost, Daniel J. Walsh, Surachai Supattapone, Stephanie A. Booth, Walker S. Jackson, Joel C. Watts   +11 more
doaj   +1 more source

Antimalarial Drug Quinacrine Binds to C-Terminal Helix of Cellular Prion Protein

, 2003
Martin Vogtherr, S. Grimme, Bettina Elshorst, Doris M. Jacobs, Klaus M. Fiebig, Christian Griesinger, Ralph Zahn   +6 more
openalex   +1 more source