Results 181 to 190 of about 3,400,014 (272)

Cellular prion protein and its derived peptides: multifaceted roles in neurodegenerative diseases and potential as biomarkers. [PDF]

Cell Biosci
Mari E, Aventaggiato M, Paldino E, Ceccarelli S, Mucci N, Bellomo G, Mantuano E, Dugheri S, Martellucci S, Mattei V.   +9 more
europepmc   +1 more source

Sugar Metabolisms Altered By Undissociated Forms of Organic Acids Based on the Emergence of [GAR+] Cells in Saccharomyces cerevisiae

Yeast, Volume 43, Issue 5, Page 223-230, September 2026.
ABSTRACT The glucose repression system is a mechanism for effective energy acquisition by glucose assimilation in microorganisms. In yeast, Saccharomyces cerevisiae, which is known as a prion‐like protein [GAR+], is involved in the bypass of glucose repression. It has been reported that the emergence of [GAR+] cells was promoted by lactate and acetate.
Koichi Tanabe, Atsuhiko Nakata, Mizuki Hosotani, Jun Shima   +3 more
wiley   +1 more source

Editorial: Prion and prion-like proteins in neurodegenerative diseases

Frontiers in Neuroscience, 2022
Toni, Mattia, Eleuteri, Simona
openaire   +4 more sources

The octapeptide repeats of prion protein play critical roles in the pathogenesis of prion diseases. [PDF]

Acta Neuropathol Commun
Zhang X, Zhang J, Zhang Y, Wang D, Liu G, Wang M, Li C, Shi Q, Dong X, Yuan C, Li W, Ma J.   +11 more
europepmc   +1 more source

Harmonized Acquisition of Connectome MRI and Clinical Data for Stroke, Parkinson's Disease and Glioma: Delphi‐Derived Protocol Recommendations by the European Academy of Neurology

European Journal of Neurology, Volume 33, Issue 9, September 2026.
In the context of the Horizon Europe EBRAINS 2.0 research consortium, Delphi‐derived, consented protocol recommendations from European Academy of Neurology Scientific Panel experts provide a pragmatic framework for harmonizing multi‐scale data acquisition for connectome analyses in stroke, Parkinson's Disease, and glioma.
Thomas Berger, Lorenzo Pini, Alessandro Salvalaggio, Simone Cauzzo, Christine Klein, Maria Lolich, Alberto Picca, Dauren Ramankulov, Maria A. Rocca, Roberta Rudà, Alessandro Sodero, Alessandro Tessitore, Thomas Truelsen, Roland Wiest, Gereon R. Fink, Elena Moro, Philippe Ryvlin, Maurizio Corbetta   +17 more
wiley   +1 more source

Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy. [PDF]

Neurobiol Dis
Gatdula JRP, Mirza-Romero NA, Orbe IC, Saunders LM, Tolton SG, Vultaggio JS, Mercer RCC, Bartz JC, Telling GC, Eraña H, Castilla J, Harris DA.   +11 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Identification and initial characterization of novel prion protein gene (<i>PRNP)</i> variants in wild Montana mule deer. [PDF]

Front Vet Sci
Seerley AL, Rothfuss MT, Gray BM, Sebogo MA, Manakelew BA, Pounder JI, Bowler BE, Leavens MJ, Grindeland Panter AL.   +8 more
europepmc   +1 more source

“S‐Tau‐Lled” Lysosomes Disrupt Autophagic Processes in Neurodegeneration

Traffic, Volume 27, Issue 3, September 2026.
Tauopathies are neurodegenerative diseases characterized by misfolded tau accumulation and lysosomal dysfunction. Pathogenic mutant Tau stalls lysosomes in iPSC‐derived neurons upstream of Tau accumulation. Pharmacological activation of autophagy activation reduces Tau burden without rescuing lysosome motility, revealing that trafficking and ...
Anaïs Bécot, Mehdi Kabani
wiley   +1 more source