Results 171 to 180 of about 3,400,014 (272)

The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein. [PDF]

PLoS Pathog
Amano G, Arshad H, Patel Z, Schmitt-Ulms G, Watts JC.   +4 more
europepmc   +1 more source

Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function

Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley   +1 more source

Prion protein (PrP) profiles in blood and CSF: insights into pre-symptomatic and symptomatic prion disease. [PDF]

Brain Commun
Laginha I, Schmitz M, da Silva Correia Â, Saleem T, da Silva Correia S, Zafar S, Younas N, Canaslan S, Göbel S, Root E, Breitbarth M, Fischer AL, Dittmar K, Žakova D, Hermann P, Zerr I.   +15 more
europepmc   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Distinctive properties of the prion protein in the brain and retina in the amyloidosis associated with the PRNP F198S mutation. [PDF]

Acta Neuropathol
Ghetti B, Glazier BS, Fiorini M, Newell KL, Bonnin JM, Murrell JR, Varner LR, Jacobsen M, Striebel JF, Priola SA, Zanusso G.   +10 more
europepmc   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Cellular Prion Protein as a Novel Regulator of Vascular Plexus Stability During Retinal Angiogenesis. [PDF]

Neurochem Res
da Rosa BG, Leser F, Alves MA, de Souza Leite E, Garcia C, Geraldo LHM, do Amaral RF, Freitas C, Lima FRS.   +8 more
europepmc   +1 more source

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, Volume 4, Issue 3, Page 262-274, September 2026.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

Piano-Stool Ru (II) Complexes as Modulators of Human Prion Protein PrP_106-126 Aggregation. [PDF]

ChemMedChem
Chauhan R, Kumawat H, Saini S, Panwar A, Kukreti P, Medda N, Roy P, Ghosh K.   +7 more
europepmc   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, Volume 15, Issue 3, Page 176-193, September 2026.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source