Results 141 to 150 of about 50,704 (271)

Mechanistic Insights Into Protein Aggregation Inhibition by Green‐Synthesized Silver Nanoparticles: A Study on Human Lysozyme

IET Nanobiotechnology, Volume 2026, Issue 1, 2026.
A characteristic of many neurodegenerative disorders, such as Parkinson’s and Alzheimer’s, is amyloidogenic protein aggregation, for which there are currently no proven cures. Aging, mutation, and physiological stress can cause proteins to deviate from their natural folding patterns, potentially leading to the formation of hazardous protein aggregates.
Md. Tauqir Alam, Mohd. Ahmar Rauf, Arman Khan, Rizwan Hussain, Anbazhagan Veerappan   +4 more
wiley   +1 more source

The Volumetric Diversity of Misfolded Prion Protein Oligomers Revealed by Pressure Dissociation [PDF]

, 2015
Joan Torrent, Reinhard Lange, Human Rezaei   +2 more
openalex   +1 more source

Development of High‐Throughput Genomic Resources to Inform White‐Tailed Deer Population and Disease Management

Molecular Ecology Resources, Volume 26, Issue 1, January 2026.
ABSTRACT White‐tailed deer (Odocoileus virginianus) are the most abundant and widespread cervid in North America. Genetic data are used as a tool to monitor populations and make management decisions for this game species. However, the development and use of genomic tools that can generate a set of markers suitable for longitudinal genomic data ...
David Navarro, Emily K. Latch, Anaïs K. Tallon, Caitlin N. Ott‐Conn, Randy W. DeYoung, Daniel P. Walsh, Peter T. Euclide, Chandika R. G., Wes A. Larson, Arun S. Seetharam, Andrew J. Severin, James M. Reecy, Zhi‐Liang Hu, Jay R. Cantrell, Michelle Carstensen, Joe N. Caudell, Charlie H. Killmaster, Mitch L. Lockwood, William T. McKinley, Andrew S. Norton, Krysten L. Schuler, Daniel J. Storm, Jason A. Sumners, W. David Walter, Julie A. Blanchong   +24 more
wiley   +1 more source

Protein inheritance (prions) based on parallel in‐register β‐sheet amyloid structures

, 2008
Reed B. Wickner, Frank Shewmaker, Dmitry Kryndushkin, Herman K. Edskes   +3 more
openalex   +2 more sources

Hydrophobic residues in the α‐synuclein NAC domain drive seed‐competent fibril formation and are targeted by peptide inhibitors

The FEBS Journal, Volume 293, Issue 1, Page 134-155, January 2026.
The hydrophobic 68GAVV71 stretch in the NAC domain of α‐synuclein is essential for nucleation, while residues 79–95 are required for fibril stability and seeding. Truncation or inhibition of 68GAVV71 prevents fibril formation, and truncation of 79–95 abolishes seeding competency, highlighting their distinct roles in α‐synuclein aggregation and ...
Viswanath Das, Sayed Mostafa Modarres Mousavi, Narendran Annadurai, Sunčica Sukur, Faramarz Mehrnejad, Sajad Moradi, Lukáš Malina, Markéta Kolaříková, Vaclav Ranc, Ivo Frydrych, Roman Kouřil, Saman Hosseinkhani, Marián Hajdúch, Maryam Nikkhah   +13 more
wiley   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Biochemical and structural studies of the prion protein polymorphism [PDF]

, 2001
Cyril Petchanikow, Gabriela P. Saborı́o, Laurence Anderes, Marie-Jose Frossard, MARIA ISABEL OLMEDO, Claudio Soto   +5 more
openalex   +1 more source

Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente, Isaac Ponce, Emmanuel Ríos‐Castro, Perla Moreno‐Castilla, Luis B. Tovar‐y‐Romo   +4 more
wiley   +1 more source

Evolution of transmissible spongiform encephalopathy and the prion protein gene ( PRNP ) in mammals [PDF]

, 2020
Brittaney L. Buchanan, Robert M. Zink
openalex   +1 more source

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications

Journal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Gastrointestinal (GI) cancers remain a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Melatonin (MEL), an indoleamine with pleiotropic biological activities, has emerged as a promising adjuvant in oncology due to its antiproliferative, proapoptotic, and antioxidant properties.
Maciej Gonciarz, Benita Wiatrak, Iga Lombard, Łukasz Konecki, Joanna Sarbinowska   +4 more
wiley   +1 more source