Results 201 to 210 of about 5,604,422 (355)

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1314-1329, August 2025.
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1330-1348, August 2025.
ABSTRACT Microglia, the resident immune‐competent cells of the brain, become dysfunctional in Alzheimer's disease (AD), and their aberrant immune responses contribute to the accumulation of pathological proteins and neuronal injury. Genetic studies implicate microglia in the development of AD, prompting interest in developing immunomodulatory therapies
Madison K. Kuhn, Elizabeth A. Proctor
wiley   +1 more source

Purification and properties of the cellular prion protein from Syrian hamster brain

, 1992
Keh‐Ming Pan, Neil Stahl, Stanley B. Prusiner   +2 more
openalex   +1 more source

Prion Protein Expression in Human Leukocyte Differentiation [PDF]

, 1998
Vincent Dodelet, Neil R. Cashman
openalex   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, Volume 182, Issue 16, Page 3800-3817, August 2025.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity.

, 1991
David A. Harris, Douglas L. Falls, F. A. Johnson, G D Fischbach   +3 more
openalex   +1 more source

Prion-Protein

Springer Reference Medizin, 2019
J. Tatzelt, F. Beraldo, G. Hajj, M. Lopes, K. Lee, M. Prado, H. El-Shemy   +6 more
semanticscholar   +1 more source

Detection of Human Prion Seeding Activity in Formalin‐Fixed Paraffin‐Embedded Archival Tissues

Neuropathology and Applied Neurobiology, Volume 51, Issue 4, August 2025.
The RT‐QuIC assay showed high sensitivity and specificity in detecting prion seeding activity in archival FFPE brain tissues, comparable to results obtained from frozen samples. Notably, prion activity remained detectable in FFPE tissues even after long‐term storage.
Soňa Baranová, Radoslav Matěj, Jiri G. Safar, Karel Holada   +3 more
wiley   +1 more source

Sphingolipid Depletion Increases Formation of the Scrapie Prion Protein in Neuroblastoma Cells Infected with Prions

, 1999
Naava Naslavsky, Hilary Shmeeda, Gérard Friedlander, Anat Yanai, Anthony H. Futerman, Yechezkel Barenholz, Albert Taraboulos   +6 more
openalex   +1 more source

Propagation of prion strains through specific conformers of the prion protein [PDF]

, 1997
Michael R. Scott, Darlene Groth, Jörg Tatzelt, Marilyn Torchia, Patrick Tremblay, S. J. DeArmond, Stanley B. Prusiner   +6 more
openalex   +1 more source