Results 221 to 230 of about 56,657 (298)

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, Volume 208, Issue 6, Page 1980-1992, June 2026.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Genetic variability of the prion protein gene (PRNP) in thin-tailed and fat-tailed sheep. [PDF]

Open Vet J
Wicaksono A, Haryanto A, Ibrahim A, Suryandari A, Puspita RAA, Purwaningrum M.   +5 more
europepmc   +1 more source

Segmental Isotope Labeling of the Prion Protein: Identification of a Key Residue for Copper-Mediated Interdomain Structure. [PDF]

ACS Chem Biol
Pavlovici FA, Singewald K, Kaplan S, Chen E, Millhauser GL.   +4 more
europepmc   +1 more source

White-Tailed Deer Prion Protein Gene Variability Suggests Selection Against Chronic Wasting Disease in Canada's Prairies. [PDF]

Viruses
Pilot W, Arifin MI, Staskevicius A, Haley NJ, Mitchell G, Guan J.   +5 more
europepmc   +1 more source

A Practice Framework for Genetic Testing in Asymptomatic Relatives of Patients With Creutzfeldt‐Jakob Disease: Experience and Insights From Israel

European Journal of Neurology, Volume 33, Issue 6, June 2026.
Presymptomatic genetic testing for genetic Creutzfeldt‐Jakob disease requires careful balancing of autonomy, psychological preparedness, and potential familial implications. Based on multidisciplinary experience in Israel, we propose a structured framework including pre‐test counseling, psychological appraisal, genetic testing, in‐person results ...
Dror Shir, Noa Bregman, Aya Bar David, Talya Nathan, Orly Goldstein, Tanya Gurevich, Avner Thaler, Anat Mirelman, Tamara Shiner, Mali Gana Weisz, Shiri Shkedi‐Rafid, Gael Ganz, Hagit Shani, Elon Pras, Odelia Chorin, Gia Sorkin, Keren Markus‐Bustani, Shlomzion Kahana Merhavi, Mor Shechory‐Stahl, Miri Yanoov Sharav, Michal Dicastro, Dorin Trigubov, Dalit Barel, Esther Kahana, Avi Fellner, Amos Korczyn, Hagit Baris Feldman, Lior Greenbaum, Nurit Omer   +28 more
wiley   +1 more source

Variably protease-sensitive prionopathy: mass spectrometry analysis of the pathogenic prion protein provides a new perspective. [PDF]

Acta Neuropathol Commun
Nemani SK, Xiao X, Notari S, Cali I, Lundberg K, Cracco L, Appleby BS, Surewicz WK, Sim VL, Gambetti P.   +9 more
europepmc   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, Volume 293, Issue 11, Page 3376-3398, June 2026.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

Role of cellular prion protein in mouse granulosa cells and its effects on ovarian function in knockout mice. [PDF]

Mol Med Rep
Cao Q, Wang H, Hu J, Wang Y, Dai T, Liu F, Yang X, Yang Q, Tu C.   +8 more
europepmc   +1 more source

Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP‐43 Proteinopathy

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
TDP‐43 pathology is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Peptidyl‐prolyl cis–trans isomerase A (PPIA), a foldase and chaperone protein, modulates TDP‐43 function in an acetylation‐dependent manner. Here, we show that inhibition of lysine deacetylation with vorinostat (SAHA) increases PPIA acetylation and ...
Serena Scozzari, Stefano Fabrizio Columbro, Monica Favagrossa, Massimo Tortarolo, Alfredo Cagnotto, Mario Salmona, Giovanni De Marco, Caterina Bendotti, Andrea Calvo, Laura Pasetto, Valentina Bonetto   +10 more
wiley   +1 more source

Prion protein promotes copper toxicity in Wilson disease. [PDF]

Nat Commun
Petruzzelli R, Catalano F, Crispino R, Polishchuk EV, Elia M, Masone A, Lavigna G, Grasso A, Battipaglia M, Sepe LV, Akdogan B, Reinold Q, Del Prete E, Carrella D, Torella A, Nigro V, Caruso E, Innocenti N, Biasini E, Puchkova LV, Indrieri A, Ilyechova EY, Piccolo P, Zischka H, Chiesa R, Polishchuk RS.   +25 more
europepmc   +1 more source