Results 211 to 220 of about 5,604,422 (355)

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

Advanced Science, Volume 12, Issue 25, July 3, 2025.
Utilizing a stereotaxic injection mouse model and a novel mathematical approach, this study uncovers key subnetworks that drive pathological α‐synuclein (α‐Syn) progression in Parkinson's disease (PD). Remarkably, just 2% of the strongest connections in the connectome are sufficient to predict its spread.
Yuanxi Li, Justin Torok, Shujing Zhang, Jessica Ding, Ning Wang, Courtney Lau, Shruti Kulkarni, Chaitali Anand, Julie Tran, Michael Cheng, Claire Lo, Binbin Lu, Yanzi Sun, Robert Damoiseaux, Xia Yang, Ashish Raj, Chao Peng   +16 more
wiley   +1 more source

Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication

, 1999
Alex J. Raeber, Andreas W. Sailer, Ivan Hegyi, Michael A. Klein, Thomas Rülicke, Marek Fischer, Sebastian Brandner, Adriano Aguzzi, Charles Weissmann   +8 more
openalex   +1 more source

A chicken monoclonal antibody with specificity for the N-terminal of human prion protein [PDF]

, 1999
Haruo Matsuda, Hiroyuki Mitsuda, Naoto Nakamura, Shuichi Furusawa, Shirou Mohri, Tetsuyuki Kitamoto   +5 more
openalex   +1 more source

Amyloid fibrils from the N-terminal prion protein fragment are infectious

Proceedings of the National Academy of Sciences of the United States of America, 2016
J. Choi, I. Cali, K. Surewicz, Qingzhong Kong, P. Gambetti, W. Surewicz   +5 more
semanticscholar   +1 more source

Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION The Down syndrome‐associated Alzheimer's disease (DSAD) autosomal dominant Alzheimer's disease (ADAD) 2024 Conference in Barcelona, convened under an Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) grant through the Down syndrome and Alzheimer's disease (AD) Professional ...
Neus Falgàs, Lucia Maure‐Blesa, Beau Ances, Lisi Flores‐Aguilar, Sigan Hartley, Jason Hassenstab, M Florencia Iulita, Matthew Janicki, Katherine Koenig, Patrick Lao, Johannes Levin, Eric McDade, Laurent Meijer, Michael S. Rafii, Heather M. Snyder, Raquel Sánchez‐Valle, Juan Fortea, DSAD‐ADAD conference group, Jose Arriola Infante, Mirea Balasa, Isabel Barroeta, Nicolas Barthelemy R, Alexandre Bejanin, Bessy Benejam, Beatriz Bosch, Angela Bradshaw, Maria Carmona‐Iragui, Ann Cohen, Aina Comas Albertí, Lajos Csincsik, A. Claudio Cuello, Laura del Hoyo Soriano, Janna Dijkstra, Natalie Edwards, Sandra Giménez, Fernando Gonzalez‐Ortiz, Brian Gordon, Sara Gutiérrez Fernández, Benjamin Handen, Charlotte Jacob, Erik Johnson, Charlotte Johansson, Albert Lladó, Alberto Lleó, Samuel Morabito, Alejandra. O. Morcillo‐Nieto, Laia Montoliu‐Gaya, Michael Okafor, Agnes Pérez‐Millan, Marie Claude Potier, John Ringman, Íñigo Rodríguez‐Baz, Eric Rubenstein, Natalie S. Ryan, André Strydom, Lidia Vaqué‐Alcázar, Lisa Vermunt, Laura Videla Toro, Shahid Zaman   +58 more
wiley   +1 more source

Ultrastructural Studies on Scrapie Prion Protein Crystals Obtained from Reverse Micellar Solutions [PDF]

, 1999
Holger Wille, Stanley B. Prusiner
openalex   +1 more source

Pathogenic mechanisms of prion protein, amyloid‐β and α‐synuclein misfolding: the prion concept and neurotoxicity of protein oligomers

Journal of Neurochemistry, 2016
Cathryn L. Ugalde, D. Finkelstein, V. Lawson, A. Hill   +3 more
semanticscholar   +1 more source

ApoE3 Christchurch and tau interaction as a protective mechanism against Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION We described a protected case with familial Alzheimer's disease, homozygous for apolipoprotein E3 (APOE3) Christchurch variant (ApoE3Ch), exhibiting low tau protein levels despite genetic predisposition to the disease due to presenilin (PSEN)1‐E280A.
Paula Perez‐Corredor, Said Arevalo‐Alquichire, Randall C. Mazzarino, Michael O'Hare, Andres F. Muriel‐Torres, Guido N. Vacano, Timothy E. Vanderleest, William P. Miller, Lina Pineda‐Lopez, Shivani Patel, Robert A. Obar, Nihat Polat, Leo A. Kim, Joseph F. Arboleda‐Velasquez, Claudia Marino   +14 more
wiley   +1 more source

Expression of Cellular Prion Protein in Activated Hepatic Stellate Cells [PDF]

, 1998
Kazuo Ikeda, Norifumi Kawada, Yan Qing Wang, Hirokazu Kadoya, Kazuki Nakatani, Makoto Sato, Kenji Kaneda   +6 more
openalex   +1 more source

Transcriptomic Insights Into Serum‐Free Medium Adaptation and Temperature Reduction in Chinese Hamster Ovary Cell Cultures

Biotechnology Journal, Volume 20, Issue 7, July 2025.
Graphical Abstract and Lay Summary Transcriptomic analysis of CHO cells exposed to different industrially relevant conditions identified cholesterol and p53‐related genes with differential expression and several new housekeeping genes. ABSTRACT Chinese hamster ovary (CHO) cells are widely used in recombinant biopharmaceutical production; yet, yields ...
Benjamin F. Synoground, Yogender Gowtham, Timothy Lindquist, Junessa Pressley, Derrick C. Scott, Christopher S. Saski, Sarah W. Harcum   +6 more
wiley   +1 more source