Results 221 to 230 of about 1,598,142 (264)

Role of Microbial Toxins in Neurodegenerative Diseases: Insights and Future Perspectives. [PDF]

Biomolecules
Singh AA, Khan F, Song M.
europepmc   +1 more source

Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy. [PDF]

Neurobiol Dis
Gatdula JRP, Mirza-Romero NA, Orbe IC, Saunders LM, Tolton SG, Vultaggio JS, Mercer RCC, Bartz JC, Telling GC, Eraña H, Castilla J, Harris DA.   +11 more
europepmc   +1 more source

Prion Diseases-When Proteins Turn Lethal: Creutzfeldt-Jakob Disease (CJD) and the Quest for Classification, Diagnosis, Therapeutic Approaches, and Emerging Research. [PDF]

Molecules
Ramesh TS, Bartusik-Aebisher D, Dynarowicz K, Aebisher D.   +3 more
europepmc   +1 more source

Prion propagation is controlled by discrete structural regions of PrP rather than overall stability. [PDF]

J Biol Chem
Bhamra SK, Arora P, Liew M, Hosszu LLP, Batchelor M, Clarke AR, Bieschke J, Collinge J, Jat PS.   +8 more
europepmc   +1 more source

NMR spectroscopy with prion proteins and prion protein fragments

, 1999
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A neural stem cell-derived 3D spheroid model that recapitulates prion infection and pathology. [PDF]

Mater Today Bio
Park HJ, Kim H, Byun S, Ryou C.
europepmc   +1 more source

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Aptamers against prion proteins and prions

Cellular and Molecular Life Sciences, 2009
Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrP(c)) into the aberrantly folded pathologic isoform PrP(Sc). RNA, DNA or peptide aptamers are classes of molecules which can be selected from complex combinatorial libraries for ...
Sabine, Gilch, Hermann M, Schätzl
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Structural Studies of Prion Proteins and Prions

2011
Prion diseases are a group of fatal and incurable neurodegenerative ­disorders of mammals. They uniquely manifest as sporadic, genetic, and infectious maladies. The agent responsible for prion diseases is the prion. A prion is defined as a proteinaceous infectious particle, which is solely constituted by an alternately folded form of the prion protein (
Legname, Giuseppe, GIACHIN G, BENETTI F.
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The fate of the prion protein in the prion/plasminogen complex

Biochemical and Biophysical Research Communications, 2003
The cellular prion protein (PrP(c)) forms complexes with plasminogen. Here, we show that the PrP(c) in this complex is cleaved to yield fragments of PrP(c). The cleavage is accelerated by plasmin but does not appear to be dependent on it.
Kornblatt, Jack A., Marchal, Stéphane, Rezaei, Human, Kornblatt, M. Judith, Balny, Claude, Lange, Reinhard, Debey, Marie-Pascale, Hui Bon Hoa, Gaston, Marden, Michael C., Grosclaude, Jeanne   +9 more
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