Results 191 to 200 of about 56,806 (329)

Transcriptional outputs and condensates – formation and function

New Phytologist, Volume 249, Issue 3, Page 1145-1154, February 2026.
Summary The dynamic spatiotemporal organization of macromolecules is key to the proper function of the cell, allowing the exquisite regulation of diverse processes from gene expression to enzymatic function. The formation of biomolecular condensates via phase separation (PS) acts as a general mechanism for selectively concentrating proteins, nucleic ...
Stephanie Hutin, Jiawei Li, Mark D. Tully, Xuelei Lai, Chloe Zubieta   +4 more
wiley   +1 more source

Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains. [PDF]

Proc Natl Acad Sci U S A
DeFranco JP, Bian J, Kim S, Atkinson ZN, Crowell J, Kang HE, Bodrogi HO, Christiansen JR, Díaz-Domínguez CM, Telling GC.   +9 more
europepmc   +1 more source

A Programmable, 3D Neuron‐On‐Chip Platform Integrating Near Real‐Time Biosensing and Multiaxial Loading for Mechanobiological Injury Profiling

Advanced Science, Volume 13, Issue 2, 9 January 2026.
A programmable 3D Neuron‐Injury‐on‐a‐Chip platform integrates multiaxial mechanical loading with ultrasensitive electrochemical biosensing to decode neuronal responses in real time. By mimicking physiologically relevant extension–torsion forces, the system reveals load‐specific biomarker trajectories (T‐Tau, NFL), gene regulation, and apoptosis.
Sultan Khetani, Kar Wey Yong, Mawafag F. Alhasadi, Amir Hamedzadeh, Leila Shahsavari, Atefeh Rafiei, Kalvin Wu, Omakhowa Agbojo, Anupriya Singh, Kunal Karan, Salvatore Federico, Arindom Sen, Amir Sanati‐Nezhad   +12 more
wiley   +1 more source

Assessment of Human BSE Risks Through the Use of <i>Cattle-Derived MBM</i> ^*1 in Chicken, Pig, and Others Feed (Prions). [PDF]

Food Saf (Tokyo)
Food Safety Commission of Japan.
europepmc   +1 more source

The protein - only theory and the yeast Saccharomyces cerevisiae: the prions and the propagons

, 2001
Eric Fernandez‐Bellot, Christophe Cullin   +1 more
openalex   +2 more sources

Prion Paradigm: Understanding NeurodegenerativeDisorders [PDF]

, 2019
Afonso Carlos Neves
openalex   +1 more source

Marginal Stability of the YB1 Cold‐Shock Domain in Cells Enables Binding of Multiple Nucleic Acids

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study suggests that the marginal stability of the YB1 Cold‐Shock Domain (CSDex) allows for a balance between multifunctionality and conformational changes under physiological conditions. This balance is driven by the dynamic equilibrium between the unfolded ensemble (UE) and the native ensemble (NE) of CSDex (PDB:6LMR).
Puja Shrestha, Sara S. Ribeiro, Janne Aurich, Christian Herrmann, Simon Ebbinghaus   +4 more
wiley   +1 more source

Prion infection [PDF]

Nature, 1991
L D, Hurst, D, Haig
openaire   +2 more sources

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Samuel Peña‐Díaz, Yanting Jiang, Zhefei Zhang, Anders Daugberg, Pedro Ferreira, Marcos López Hernández, Chandrika Mittal, Maria Joao Ramos, Jan Skov Pedersen, Morten Kam Dahl Dueholm, Cao Qin, Huabing Wang, Daniel E. Otzen   +12 more
wiley   +1 more source

Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions. [PDF]

PLoS Pathog
Beauchemin KS, Kun J, Groveman B, Williams K, Salerno F, Francomacaro LM, Robison P, Haigh CL, Supattapone S.   +8 more
europepmc   +1 more source