Results 211 to 220 of about 48,246 (290)

Transmission of multiple system atrophy prions to transgenic mice

Proceedings of the National Academy of Sciences of the United States of America, 2013
J. Watts, K. Giles, Abby Oehler, L. Middleton, D. Dexter, S. Gentleman, S. DeArmond, S. Prusiner   +7 more
semanticscholar   +1 more source

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases. [PDF]

Acta Neuropathol
Masone A, Grasso A, Comerio L, Bruno R, Lavigna G, Vanni I, D'Agostino C, Orrù CD, Caughey B, Altmeppen HC, Castilla J, Giaccone G, Tagliavini F, Di Bari MA, Nonno R, Chiesa R.   +15 more
europepmc   +1 more source

Association of recurrence patterns and outcome with HR and HER2 status in patients with resected brain metastases from breast cancer

International Journal of Cancer, Volume 159, Issue 2, Page 440-449, 15 July 2026.
What's new? While treatment strategies for solid brain metastases have been relatively uniform across cancer subtypes, tailored approaches are warranted. In this observational study, intracranial recurrences after microsurgical resection occurred significantly earlier and more frequently at distant sites in patients with triple‐negative breast cancer ...
Jonathan Weller, Sophie Katzendobler, Frederic Thiele, Anna Riesberg, Patrick N. Harter, Frederick Klauschen, Rachel Wuerstlein, Stephan Schoenecker, Montserrat Pazos Escudero, Robert Forbrig, Niklas Thon, Florian Ringel, Michael Weller, Emilie Le Rhun, Veit M. Stoecklein   +14 more
wiley   +1 more source

Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness. [PDF]

Acta Neuropathol Commun
Eraña H, Vidal E, Fernández-Borges N, Charco JM, Díaz-Domínguez CM, Sampedro-Torres-Quevedo C, San-Juan-Ansoleaga M, Fernández-Muñoz E, Galarza-Ahumada J, Pérez-Castro MÁ, Gonçalves-Anjo N, Piñeiro P, Pirisinu L, Di Bari MA, Giler S, Raimondi I, Espinosa JC, Vanni I, D'Agostino C, Rodríguez-Cuesta J, Pasetto L, Bonetto V, González-Martín N, Teijeira S, Zou WQ, Geijo M, Torres JM, Chiesa R, Sánchez-Martín MA, Nonno R, Requena JR, Castilla J.   +31 more
europepmc   +1 more source

FMRP‐Mediated Proteasome Regulation: A Novel Mechanism in ALS Pathology

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Schematic model of TDP‐43/TNKS‐mediated proteasome regulation in WT, FMRP‐depleted, and TDP‐43A315T‐Tg ALS neurons. In WT neurons, cytoplasmic TDP‐43 partially sequesters TNKS, maintaining balanced PI31 ribosylation and proteasome activity. FMRP depletion promotes nuclear translocation of TDP‐43, enhances TNKS/PI31 interaction, and increases axonal ...
Pritha Majumder, Asmar Ahsan, Pitchapa Bubphachat, Khadiza Akter, Jeffrey K. Huang, Chi‐Chen Sarah Huang   +5 more
wiley   +1 more source

Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions. [PDF]

PLoS Pathog
Beauchemin KS, Kun J, Groveman B, Williams K, Salerno F, Francomacaro LM, Robison P, Haigh CL, Supattapone S.   +8 more
europepmc   +1 more source

Mechanistic Insights Into Metal Binding in the Aggregation Pathway of an Immunoglobulin Light Chain Protein

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Cardiac antibody light chain (AL) amyloidosis is characterized by the deposition of light chain (LC) variable domain (VL) protein in the heart. Transition metals such as copper and zinc have been suggested to enhance the toxicity of circulating soluble LCs. We show here how divalent metal ions influence the aggregation behavior of the patient‐derived λ‐
Tejaswini Pradhan, Riddhiman Sarkar, Joshua Leonhard‐Preu, Adrian F. Schnell, Nadine Schwierz, Bernd Reif   +5 more
wiley   +1 more source

Modeling chronic wasting disease transmission risk in mule deer related to habitat characteristics. [PDF]

PLoS One
Christensen EM, Kleist NJ, Edmunds DR, Heinrichs JA, Saher DJ, Whipple AL, DeVivo M, Aldridge CL.   +7 more
europepmc   +1 more source

Involvement of the spleen in the anti-prion activity of hydroxypropyl methylcellulose in mice. [PDF]

Sci Rep
Teruya K, Oguma A, Nishizawa K, Doh-Ura K.   +3 more
europepmc   +1 more source

A brief history of prions.

Pathogens and Disease, 2015
M. Zabel, C. Reid
semanticscholar   +1 more source