Results 211 to 220 of about 37,766 (292)

In silico peptide self‐assembly reveals the importance of N‐terminal motifs and the inhibition mechanism of the mutation L38M in α‐synuclein fibrillation

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Alpha‐synuclein (αSyn) is a presynaptic protein associated with several neurodegenerative diseases. While the non‐amyloid component (NAC) region of the αSyn sequence (residues 65–90) forms the core of all αSyn fibrils, recent findings suggest that the flanking regions play a key role in initiating or preventing amyloid formation. Two motifs in
Van T. T. Nguyen, Sabine M. Ulamec, David J. Brockwell, Sheena E. Radford, Carol K. Hall   +4 more
wiley   +1 more source

Scalable assay to identify inhibitors of prion‐like propagation of protein misfolding as potential therapeutics for neurodegeneration

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Protein misfolding is linked to many neurodegenerative diseases. In some cases, misfolding can propagate through a prion‐like mechanism whereby natively folded molecules are converted into more copies of the misfolded isoform. Prion‐like propagation of misfolding is an attractive therapeutic target, but difficulties with assaying conversion ...
Abhishek Narayan, Krishna Neupane, Michael T. Woodside   +2 more
wiley   +1 more source

Neuroprotection trial design in progressive supranuclear palsy: challenges and solutions

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract INTRODUCTION We review the specific challenges posed to neuroprotective trial design by progressive supranuclear palsy (PSP), a rare disorder difficult to diagnose and to assess quantitatively. METHODS Focusing on reducing the size and cost of trials, we review elements of PSP neuroprotection trial methodology and formulate a new minimum ...
Lawrence I. Golbe, Ronald G. Thomas
wiley   +1 more source

State of the art in biosafety at the European National Reference Laboratories for Transmissible Spongiform Encephalopathies. [PDF]

Front Public Health
Begovoeva M, Nonno R, Mazza M, Bozzetta E, Ru G, Colleagues of the European Network of National Reference Laboratories for Transmissible Spongiform Encephalopathies.   +5 more
europepmc   +1 more source

Gut Luminal Exosomes in Young and Old Mice: Multi‐Omic Characteristics and Regulation of Gut Permeability

Aging Cell, Volume 25, Issue 4, April 2026.
This graphical abstract shows that gut luminal exosomes (LFEs) change with aging, with old mice producing LFEs that disrupt gut barrier integrity, alter microbiome composition, and promote insulin resistance. In contrast, LFEs from young mice improve gut barrier function and metabolic health, and transferring these LFEs can partially reverse age ...
Abdelnaby Khalyfa, Lyu Zhen, Trupti Joshi, David Gozal   +3 more
wiley   +1 more source

BOLL‐Containing Aggregates Mediate the Translational Regulation During Human Oogenesis

Cell Proliferation, Volume 59, Issue 4, April 2026.
This work elucidates that BOLL‐containing aggregate‐mediated translational control is essential for human oogenesis. These aggregates recruit PABPC1 and FXR1 to activate the translation of U‐rich mRNAs encoding cell cycle proteins, thereby ensuring successful meiotic progression.
Ying Li, Lingya Mao, Boyuan Liang, Longxin Xie, Wenpei Xiang, Kehkooi Kee   +5 more
wiley   +1 more source

Infecting human brain organoids with FFI or sCJD preserves prion traits regardless of host genotype. [PDF]

NPJ Dement
Groveman BR, Foliaki ST, Williams K, Orrù CD, Race B, Zanusso G, Haigh CL.   +6 more
europepmc   +1 more source

Resolving the ‘Identification Gap’ to Uncover Sympatric Seabird Distributions

Diversity and Distributions, Volume 32, Issue 4, April 2026.
ABSTRACT Aim Accurate identification underpins effective conservation, shaping our understanding of species distributions and conservation. Yet for many taxa, diagnostic criteria remain poorly resolved, creating an ‘identification gap’ that limits the capacity of scientists and environmental managers to study, monitor, and protect them. We examined the
Simon B. Z. Gorta, Peter Allen
wiley   +1 more source

3D atomic structure reveals evolution of prions in templated amplification in vitro

Bieschke J, Wenborn A, Chatzitheodosiou I, Jack K, Batchelor M, Chen L, Ahmed P, Thirlway G, Manka S, Jackson G, Wadsworth J, Collinge J.   +11 more
europepmc   +1 more source

Mutant knock-in mice display enhanced susceptibility to pure prion protein fibrils. [PDF]

J Gen Virol
Walsh DJ, Standke H, Kraus A, Watts JC, Supattapone S.   +4 more
europepmc   +1 more source