Results 221 to 230 of about 37,766 (292)

Reductionism in Engram Neuroscience

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
Reductionist methods inspire several seemingly incompatible explanations and ontologies. But such adversarial approaches can be fruitful for theorising in neuroscience. We argue that reductionist methods are at their most useful when coupled with integrative practices that include multiple heterarchical levels of organisation, various kinds of analysis,
Caitlin Mace, Fionn O'Sullivan, Scott R. Wilson   +2 more
wiley   +1 more source

Contrasting roles of autophagy in cellular prion infection. [PDF]

Autophagy
Abdulrahman B, Heiseke A, Aguib Y, Lu L, Abdelaziz D, Ansari M, Thapa S, Taguchi Y, Gilch S, Schätzl HM.   +9 more
europepmc   +1 more source

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

The FEBS Journal, Volume 293, Issue 7, Page 2086-2097, April 2026.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos, Jéssica Sarabando, Mariana Marques, Jonathan C. Kagan, Daniela Ribeiro   +4 more
wiley   +1 more source

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro, Sofia P. Agostinho, Luiz F. Piochi, Nícia Rosário‐Ferreira, Irina S. Moreira   +4 more
wiley   +1 more source

Yeast Prions: Discovery, Nature, Cellular Manipulation and Implication. [PDF]

J Microbiol Biotechnol
Son M.
europepmc   +1 more source

Possible alignment of the EU BSE surveillance with the new WOAH provisions

EFSA Journal, Volume 24, Issue 4, April 2026.
Abstract The European Commission requested the assessment of the capacity of the surveillance provisions of the World Organization for Animal Health (WOAH) to detect bovine spongiform encephalopathy (BSE) cases (C‐, H‐ and L‐type) in the European Union (EU) and to propose if any current EU surveillance provisions should be kept.
EFSA Panel on Animal Health and Welfare (AHAW), Søren Saxmose Nielsen, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Angel Miranda Chueca, Eleonora Nannoni, Anja B. Riber, Karl Stahl, Jan Arend Stegeman, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Mark Arnold, Christian Ducrot, John Griffin, Giuseppe Ru, Marion Simmons, Sean Ashe, Angel Ortiz‐ Pelaez, Kamela Kryemadhi, Romolo Nonno   +25 more
wiley   +1 more source

The impact of formic acid treatment on brain tissues for prion inactivation. [PDF]

Acta Histochem
Shaaban D, Seerley A, Crew L, Kaylor C, McElroy S, Guter E, Pounder J, Panter AG.   +7 more
europepmc   +1 more source

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Haijiang Wang, Xinxin Liu, Gido Gravesteijn, Alessia Atella, Jin Liu, Julie W. Rutten, Peter ten Dijke, Manuel A. F. V. Gonçalves, Saskia A. J. Lesnik Oberstein, David A. Baker   +9 more
wiley   +1 more source

Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets. [PDF]

Microbiol Mol Biol Rev
Caughey B, Artikis E, Shoup D, Orrú CD, Alam P, Parveen S, King S, Soukup J, Hughson AG, Priola SA.   +9 more
europepmc   +1 more source

Human PrP E219K: a new and promising substrate for robust RT-QuIC amplification of human prions with potential for strain discrimination. [PDF]

Microbiol Spectr
Marín-Moreno A, Reine F, Jaffrézic F, Herzog L, Rezaei H, Quadrio I, Haïk S, Béringue V, Martin D.   +8 more
europepmc   +1 more source