A genome‐wide association study (GWAS) was conducted to analyse variations in white blood cell (WBC) counts and composition traits among 200 Holstein cows in Southern China. The results identified two candidate genes, BEND5 and FOXJ3, associated with WBC count, lymphocyte percentage and basophil percentage.
Chenhui Liu +10 more
wiley +1 more source
D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases. [PDF]
Masone A +15 more
europepmc +1 more source
Prions and Protein Assemblies that Convey Biological Information in Health and Disease.
David W. Sanders +3 more
semanticscholar +1 more source
Epidemiology of progressive intellectual and neurological deterioration in UK children
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity +3 more
wiley +1 more source
Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness. [PDF]
Eraña H +31 more
europepmc +1 more source
Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions. [PDF]
Beauchemin KS +8 more
europepmc +1 more source
Silent Propagation of Classical Scrapie Prions in Homozygous K<sub>222</sub> Transgenic Mice. [PDF]
Fernández-Borges N +5 more
europepmc +1 more source
Prions: Beyond a Single Protein
Alvin S. Das, W. Zou
semanticscholar +1 more source
Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari +6 more
wiley +1 more source

