Resistance of soil-bound prions to rumen digestion. [PDF]
PLoS ONE, 2012 Before prion uptake and infection can occur in the lower gastrointestinal system, ingested prions are subjected to anaerobic digestion in the rumen of cervids and bovids.
Samuel E Saunders +2 more
doaj +1 more source
Distinct amino acid compositional requirements for formation and maintenance of the [PSI+] prion in yeast [PDF]
, 2015 Multiple yeast prions have been identified that result from the structural conversion of proteins into a self-propagating amyloid form. Amyloid-based prion activity in yeast requires a series of discrete steps.
Ben-Musa, Zobaida +6 more
core +2 more sources
Defining the conformational features of anchorless, poorly neuroinvasive prions. [PDF]
PLoS Pathogens, 2013 Infectious prions cause diverse clinical signs and form an extraordinary range of structures, from amorphous aggregates to fibrils. How the conformation of a prion dictates the disease phenotype remains unclear.
Cyrus Bett +9 more
doaj +1 more source
Efficient interspecies transmission of synthetic prions.
PLoS Pathogens, 2021 Prions are comprised solely of PrPSc, the misfolded self-propagating conformation of the cellular protein, PrPC. Synthetic prions are generated in vitro from minimal components and cause bona fide prion disease in animals.
Alyssa J Block +6 more
doaj +1 more source
Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. [PDF]
PLoS ONE, 2017 In our previous study, we demonstrated the propagation of mouse-passaged scrapie isolates with long incubation periods (L-type) derived from natural Japanese sheep scrapie cases in murine hypothalamic GT1-7 cells, along with disease-associated prion ...
Kohtaro Miyazawa +5 more
doaj +1 more source
Neurobiology of Disease, 2012 With an estimated life-time prevalence of 15 to 17% and an incapacitating illness in 50% of cases, depressive spectrum disorders represent a heavy public health burden.
Sophie Mouillet-Richard +3 more
doaj +1 more source
Transboundary and Emerging Diseases, 2018 A number of prion diseases affect humans, including Creutzfeldt-Jakob disease; most of these are due to genetic mutations in the affected individual and occur sporadically, but some result from transmission of prion proteins from external sources. Of the
L. Waddell +5 more
semanticscholar +1 more source
Protease-sensitive synthetic prions. [PDF]
PLoS Pathogens, 2010 Prions arise when the cellular prion protein (PrP(C)) undergoes a self-propagating conformational change; the resulting infectious conformer is designated PrP(Sc).
David W Colby +9 more
doaj +1 more source
Strain Traits of Intracranially Administered L-Type Bovine Spongiform Encephalopathy Prions Are not Significantly Modified During Intraspecies Transmission in Cynomolgus Monkeys. [PDF]
Microbiol ImmunolABSTRACT Among the three prion strains of bovine spongiform encephalopathy (BSE), classical BSE (C‐BSE) prions are known causative agents of variant Creutzfeldt–Jakob disease. By contrast, human infections with L‐type (L‐) or H‐type (H‐) BSE prions have not been reported.
Hagiwara K +8 more
europepmc +2 more sources
Cross infection control measures and the treatment of patients at risk of Creutzfeldt Jakob disease in UK general dental practice [PDF]
, 2001 AIMS: To determine the suitability of key infection control measures currently employed in UK dental practice for delivery of dental care to patients at risk of prion diseases.
A Smith +22 more
core +1 more source