Results 161 to 170 of about 16,731 (246)

Membrane-anchored PrPSc is the trigger for prion synaptotoxicity. [PDF]

PLoS Pathog
Gatdula JRP, Mercer RCC, Alepuz Guillen JA, Vultaggio JS, Harris DA.   +4 more
europepmc   +1 more source

Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions. [PDF]

PLoS Pathog
Beauchemin KS, Kun J, Groveman B, Williams K, Salerno F, Francomacaro LM, Robison P, Haigh CL, Supattapone S.   +8 more
europepmc   +1 more source

Characterization of the prion protein in relation to normal cellular function and in disease

, 2012
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of rare and fatal neurodegenerative disorders that can affect both human and animals. Evidence indicates that the key event in prion disease pathogenesis is the conformational conversion of the normal cellular prion protein (PrPC) into an aggregated isoform ...
openaire   +1 more source

Yeast Prions: Discovery, Nature, Cellular Manipulation and Implication. [PDF]

J Microbiol Biotechnol
Son M.
europepmc   +1 more source

State of the art in biosafety at the European National Reference Laboratories for Transmissible Spongiform Encephalopathies. [PDF]

Front Public Health
Begovoeva M, Nonno R, Mazza M, Bozzetta E, Ru G, Colleagues of the European Network of National Reference Laboratories for Transmissible Spongiform Encephalopathies.   +5 more
europepmc   +1 more source

Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo. [PDF]

Acta Neuropathol
Hill E, Patel MM, Ribes JM, Linehan J, Zhang F, Jakubcova T, Hamdan S, Tomlinson A, Ercolani T, Schmidt C, Ahmed P, Thirlway G, Argentina F, Marinho AT, Jones E, Kaye N, Fitzhugh C, Jackson GS, Brandner S, Klöhn PC, Collinge J, Cunningham TJ, Mead S.   +22 more
europepmc   +1 more source

Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases. [PDF]

Acta Neuropathol Commun
Wang Y, Mohammadi B, Hartmann C, Hartmann K, Thies E, Matamoros-Angles A, Fang C, Harris DA, Tatzelt J, Altmeppen HC, Sepulveda-Falla D, Strittmatter SM, Glatzel M, Krasemann S.   +13 more
europepmc   +1 more source

Beyond prion-like spreading in neurodegenerative disease. [PDF]

Alzheimers Dement
Meisl G, Rowe JB, Klenerman D.
europepmc   +1 more source

Infecting human brain organoids with FFI or sCJD preserves prion traits regardless of host genotype. [PDF]

NPJ Dement
Groveman BR, Foliaki ST, Williams K, Orrù CD, Race B, Zanusso G, Haigh CL.   +6 more
europepmc   +1 more source

The Strain Properties of Korean and North American Chronic Wasting Disease Prions Are Indistinguishable. [PDF]

J Infect Dis
Sohn HJ, DeFranco JP, Park HC, Park KJ, Bian J, Crowell J, Kim S, Webster BK, Kang HE, Telling GC.   +9 more
europepmc   +1 more source